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    Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [ Mus musculus (house mouse) ]

    Gene ID: 208715, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hmgcs1provided by MGI
    Official Full Name
    3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1provided by MGI
    Primary source
    MGI:MGI:107592
    See related
    Ensembl:ENSMUSG00000093930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130032C06Rik
    Expression
    Broad expression in CNS E18 (RPKM 127.4), CNS E14 (RPKM 70.2) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Hmgcs1 in Genome Data Viewer
    Location:
    13 D2.3; 13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (120151887..120169796)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (119690351..119708260)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NT_110857.1 (114710..132325, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53794 Neighboring gene RIKEN cDNA 1700074H08 gene Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene predicted gene, 52026 Neighboring gene predicted gene, 41077 Neighboring gene zinc finger protein 131

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36662, MGC98430

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydroxymethylglutaryl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydroxymethylglutaryl-CoA synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hydroxymethylglutaryl-CoA synthase, cytoplasmic
    Names
    3-hydroxy-3-methylglutaryl coenzyme A synthase
    HMG-CoA synthase
    NP_001278368.1
    NP_666054.2
    XP_006517641.1
    XP_036013850.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291439.1NP_001278368.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic

      See identical proteins and their annotated locations for NP_001278368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK031297, AK044835, CJ071929
      Consensus CDS
      CCDS56901.1
      UniProtKB/Swiss-Prot
      Q8JZK9
      Related
      ENSMUSP00000136944.2, ENSMUST00000179869.3
      Conserved Domains (1) summary
      TIGR01833
      Location:13469
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    2. NM_145942.5NP_666054.2  hydroxymethylglutaryl-CoA synthase, cytoplasmic

      See identical proteins and their annotated locations for NP_666054.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK031297, AK044835, CJ071929
      Consensus CDS
      CCDS56901.1
      UniProtKB/Swiss-Prot
      Q8JZK9
      Related
      ENSMUSP00000153064.2, ENSMUST00000224188.2
      Conserved Domains (1) summary
      TIGR01833
      Location:13469
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      120151887..120169796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517578.3XP_006517641.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

      See identical proteins and their annotated locations for XP_006517641.1

      UniProtKB/Swiss-Prot
      Q8JZK9
      Conserved Domains (1) summary
      TIGR01833
      Location:13469
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    2. XM_036157957.1XP_036013850.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

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