Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 14128, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fcer2aprovided by MGI
    Official Full Name
    Fc receptor, IgE, low affinity II, alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:95497
    See related
    Ensembl:ENSMUSG00000005540
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD23; Fce2; Ly-4; Fcer2; Ly-42
    Expression
    Broad expression in spleen adult (RPKM 10.2), mammary gland adult (RPKM 7.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fcer2a in Genome Data Viewer
    Location:
    8 A1.1; 8 1.92 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3730280..3744174, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3680280..3694174, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (3681737..3694174, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45231 Neighboring gene Foxo1 corepressor Neighboring gene trafficking protein particle complex 5 Neighboring gene C-type lectin domain family 4, member g Neighboring gene predicted gene 16553 Neighboring gene CD209a antigen

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgE binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    low affinity immunoglobulin epsilon Fc receptor
    Names
    FC epsilon RII
    fc-epsilon-RII
    low-affinity IgE receptor
    lymphocyte IgE receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253737.1NP_001240666.1  low affinity immunoglobulin epsilon Fc receptor isoform B

      See identical proteins and their annotated locations for NP_001240666.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform B) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS85494.1
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000146568.2, ENSMUST00000208492.2
      Conserved Domains (2) summary
      cd03590
      Location:185305
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:72169
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001253739.1NP_001240668.1  low affinity immunoglobulin epsilon Fc receptor isoform C

      See identical proteins and their annotated locations for NP_001240668.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform C) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS85491.1
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000146647.2, ENSMUST00000208145.2
      Conserved Domains (2) summary
      cd03590
      Location:185305
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:72169
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    3. NM_001253743.1NP_001240672.1  low affinity immunoglobulin epsilon Fc receptor isoform A precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform D) is shorter when it is compared to isoform A.
      Source sequence(s)
      AC087183, M34163
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000146689.2, ENSMUST00000207635.2
      Conserved Domains (2) summary
      cd03590
      Location:159279
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:46143
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. NM_001253745.1NP_001240674.1  low affinity immunoglobulin epsilon Fc receptor isoform E

      See identical proteins and their annotated locations for NP_001240674.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform E) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform E has also been called Fc epsilon receptor II subtype b variant b delta 5.
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS85492.1
      UniProtKB/Swiss-Prot
      P20693
      UniProtKB/TrEMBL
      Q8VH33
      Related
      ENSMUSP00000146380.2, ENSMUST00000208603.2
      Conserved Domains (2) summary
      cd03590
      Location:164284
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:72148
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. NM_001253746.1NP_001240675.1  low affinity immunoglobulin epsilon Fc receptor isoform F

      See identical proteins and their annotated locations for NP_001240675.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform F) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform F has also been called Fc epsilon receptor II subtype b variant b delta 6.
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS85493.1
      UniProtKB/Swiss-Prot
      P20693
      UniProtKB/TrEMBL
      Q8VH32
      Related
      ENSMUSP00000146822.2, ENSMUST00000208438.2
      Conserved Domains (2) summary
      cd03590
      Location:164284
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23765
      Location:70127
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    6. NM_001253747.1NP_001240676.1  low affinity immunoglobulin epsilon Fc receptor isoform G

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform G) is shorter when it is compared to isoform A.
      Source sequence(s)
      AC087183, M34163
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000147052.2, ENSMUST00000207463.2
      Conserved Domains (2) summary
      cd03590
      Location:146266
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:33130
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    7. NM_013517.4NP_038545.1  low affinity immunoglobulin epsilon Fc receptor isoform A

      See identical proteins and their annotated locations for NP_038545.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform A).
      Source sequence(s)
      AC087183, M34163
      Consensus CDS
      CCDS22071.1
      UniProtKB/Swiss-Prot
      P20693
      Related
      ENSMUSP00000005678.5, ENSMUST00000005678.6
      Conserved Domains (2) summary
      cd03590
      Location:186306
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      cl23720
      Location:73170
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      3730280..3744174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508697.5XP_006508760.1  low affinity immunoglobulin epsilon Fc receptor isoform X1

      Conserved Domains (2) summary
      cd03590
      Location:190310
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      TIGR04211
      Location:77175
      SH3_and_anchor; SH3 domain protein
    Support Center