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    Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B [ Mus musculus (house mouse) ]

    Gene ID: 271047, updated on 23-Jun-2021

    Summary

    Official Symbol
    Serpina3bprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3Bprovided by MGI
    Primary source
    MGI:MGI:2182835
    See related
    Ensembl:ENSMUSG00000066364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6A; 6A1; ant; A030003A19Rik
    Expression
    Biased expression in mammary gland adult (RPKM 1.6), testis adult (RPKM 0.4) and 6 other tissues See more
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    Genomic context

    See Serpina3b in Genome Data Viewer
    Location:
    12; 12 E
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104094245..104105805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104127986..104139546)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (105366206..105377755)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 5 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3A Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3C Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3D, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine protease inhibitor A3B
    Names
    alpha-1 antiproteinase
    antitrypsin
    serine (or cysteine) proteinase inhibitor, clade A, member 3B
    serpin A3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173024.3NP_766612.1  serine protease inhibitor A3B precursor

      See identical proteins and their annotated locations for NP_766612.1

      Status: PROVISIONAL

      Source sequence(s)
      AC142112
      Consensus CDS
      CCDS26147.1
      UniProtKB/Swiss-Prot
      Q8BYY9
      UniProtKB/TrEMBL
      Q05A44
      Related
      ENSMUSP00000082127.3, ENSMUST00000085052.3
      Conserved Domains (1) summary
      cl00137
      Location:51414
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104094245..104105805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515931.2XP_006515994.1  serine protease inhibitor A3B isoform X1

      Conserved Domains (1) summary
      cd19551
      Location:37403
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin
    2. XM_017315087.2XP_017170576.1  serine protease inhibitor A3B isoform X2

      Conserved Domains (1) summary
      cl38926
      Location:1203
      serpin; SERine Proteinase INhibitors (serpin) family
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