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    Apoh apolipoprotein H [ Mus musculus (house mouse) ]

    Gene ID: 11818, updated on 5-Jul-2021

    Summary

    Official Symbol
    Apohprovided by MGI
    Official Full Name
    apolipoprotein Hprovided by MGI
    Primary source
    MGI:MGI:88058
    See related
    Ensembl:ENSMUSG00000000049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B2G; B2GPI; beta-2-; beta2-GPI; beta-2-GPI
    Expression
    Biased expression in liver E18 (RPKM 1780.2), liver adult (RPKM 813.8) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Apoh in Genome Data Viewer
    Location:
    11 E1; 11 71.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (108286123..108305222)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (108395297..108414396)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (108256611..108275710)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protein kinase C, alpha Neighboring gene predicted gene 11655 Neighboring gene predicted gene, 36709 Neighboring gene centrosomal protein 112 Neighboring gene centrosomal protein 112, opposite strand 1 Neighboring gene predicted gene, 51924

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipoprotein lipase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood coagulation, intrinsic pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chylomicron ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    beta-2-glycoprotein 1
    Names
    APC inhibitor
    activated protein C-binding protein
    apo-H
    beta(2)GPI
    beta-2-glycoprotein I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013475.4NP_038503.4  beta-2-glycoprotein 1 precursor

      See identical proteins and their annotated locations for NP_038503.4

      Status: VALIDATED

      Source sequence(s)
      AA273732, AK010926, BU756628, BY143138
      Consensus CDS
      CCDS25574.1
      UniProtKB/Swiss-Prot
      Q01339
      UniProtKB/TrEMBL
      Q9CY42
      Related
      ENSMUSP00000000049.6, ENSMUST00000000049.6
      Conserved Domains (4) summary
      cd00033
      Location:84137
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:22260
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:142200
      Sushi; Sushi repeat (SCR repeat)
      pfam09014
      Location:261345
      Sushi_2; Beta-2-glycoprotein-1 fifth domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      108286123..108305222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532042.1XP_006532105.1  beta-2-glycoprotein 1 isoform X1

      Conserved Domains (2) summary
      PHA02927
      Location:22169
      PHA02927; secreted complement-binding protein; Provisional
      pfam09014
      Location:170254
      Sushi_2; Beta-2-glycoprotein-1 fifth domain
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