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    Scly selenocysteine lyase [ Mus musculus (house mouse) ]

    Gene ID: 50880, updated on 23-Jun-2021

    Summary

    Official Symbol
    Sclyprovided by MGI
    Official Full Name
    selenocysteine lyaseprovided by MGI
    Primary source
    MGI:MGI:1355310
    See related
    Ensembl:ENSMUSG00000026307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; SCL; Scly1; Scly2; 9830169H08; A930015N15Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 39.6), liver adult (RPKM 37.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Scly in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91226017..91248802)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91298295..91321080)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (93194915..93217657)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2F (putative) Neighboring gene zinc finger protein 330 pseudogene Neighboring gene espin-like Neighboring gene kelch-like 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables selenocysteine lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin B6 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    selenocysteine lyase
    Names
    mSCL
    selenocysteine lyase; Selenocysteine reductase
    selenocysteine reductase
    NP_057926.2
    XP_006529806.2
    XP_006529807.1
    XP_006529808.1
    XP_006529809.1
    XP_036008194.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016717.3NP_057926.2  selenocysteine lyase

      See identical proteins and their annotated locations for NP_057926.2

      Status: VALIDATED

      Source sequence(s)
      AK036750, BB140476, BY599687
      Consensus CDS
      CCDS15159.1
      UniProtKB/Swiss-Prot
      Q9JLI6
      UniProtKB/TrEMBL
      A0A0R4J069
      Related
      ENSMUSP00000027532.7, ENSMUST00000027532.13
      Conserved Domains (2) summary
      COG1104
      Location:18428
      NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]
      pfam00266
      Location:20416
      Aminotran_5; Aminotransferase class-V

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91226017..91248802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529744.4XP_006529807.1  selenocysteine lyase isoform X2

      Conserved Domains (1) summary
      COG1104
      Location:66474
      NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]
    2. XM_006529746.4XP_006529809.1  selenocysteine lyase isoform X5

      Conserved Domains (1) summary
      cl18945
      Location:1356
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    3. XM_006529743.2XP_006529806.2  selenocysteine lyase isoform X1

      Conserved Domains (1) summary
      COG1104
      Location:40450
      NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]
    4. XM_036152301.1XP_036008194.1  selenocysteine lyase isoform X3

      Conserved Domains (1) summary
      COG1104
      Location:44454
      NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]
    5. XM_006529745.4XP_006529808.1  selenocysteine lyase isoform X4

      Conserved Domains (1) summary
      COG1104
      Location:28438
      NifS; Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme [Amino acid transport and metabolism]

    RNA

    1. XR_387181.5 RNA Sequence

    2. XR_003956210.1 RNA Sequence

    3. XR_003956213.1 RNA Sequence

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