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    Vdac1 voltage-dependent anion channel 1 [ Mus musculus (house mouse) ]

    Gene ID: 22333, updated on 22-Aug-2021

    Summary

    Official Symbol
    Vdac1provided by MGI
    Official Full Name
    voltage-dependent anion channel 1provided by MGI
    Primary source
    MGI:MGI:106919
    See related
    Ensembl:ENSMUSG00000020402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vda; Vdac5; mVDAC1; mVDAC5; AL033343
    Summary
    This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Multiple pseudogenes of this gene are found on chromosomes 1, 2, 3, 6, 8, 9, and X. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in heart adult (RPKM 147.4), kidney adult (RPKM 93.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Vdac1 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.86 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52251678..52280224)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52360851..52389397)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (52174617..52202898)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene S-phase kinase-associated protein 1 Neighboring gene transcription factor 7, T cell specific Neighboring gene predicted gene, 30217 Neighboring gene RIKEN cDNA 9530068E07 gene Neighboring gene elastin-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables voltage-gated anion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of mitochondrial permeability transition pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    voltage-dependent anion-selective channel protein 1
    Names
    outer mitochondrial membrane protein porin 1
    plasmalemmal porin
    voltage-dependent anion-selective channel protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362693.1NP_001349622.1  voltage-dependent anion-selective channel protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645589, AL713864, BE952281
      Conserved Domains (1) summary
      cd07306
      Location:86364
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    2. NM_011694.6NP_035824.1  voltage-dependent anion-selective channel protein 1 isoform 2

      See identical proteins and their annotated locations for NP_035824.1

      Status: VALIDATED

      Source sequence(s)
      AK169160, AL713864, BE952281, CK621340
      Consensus CDS
      CCDS24671.1
      UniProtKB/Swiss-Prot
      Q60932
      Related
      ENSMUSP00000099819.2, ENSMUST00000102758.8
      Conserved Domains (1) summary
      cd07306
      Location:4282
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      52251678..52280224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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