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    Slc22a18 solute carrier family 22 (organic cation transporter), member 18 [ Mus musculus (house mouse) ]

    Gene ID: 18400, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slc22a18provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 18provided by MGI
    Primary source
    MGI:MGI:1336884
    See related
    Ensembl:ENSMUSG00000000154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BWR; HET; IMP; ITM; Orc; TSS; BWSC; Slc2; BWR1A; Impt1; TSSC5; Orctl2; p45-BW; BWSCR1A; AW260131; Slc22a1l; p45-BWR1A
    Expression
    Biased expression in kidney adult (RPKM 388.3), duodenum adult (RPKM 122.8) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc22a18 in Genome Data Viewer
    Location:
    7 F5; 7 88.22 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143027463..143053071)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143473726..143499334)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (150659660..150685239)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase inhibitor 1C (P57) Neighboring gene predicted gene, 33663 Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene predicted gene, 23297

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 18
    Names
    ORCTL-2
    imprinted multi-membrane spanning polyspecific transporter-related protein 1
    organic cationic transporter-like 2
    tumor suppressing subtransferable candidate 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042760.2NP_001036225.1  solute carrier family 22 member 18

      See identical proteins and their annotated locations for NP_001036225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' non-coding exon; hence, differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB012084, BU758157
      Consensus CDS
      CCDS22041.1
      UniProtKB/Swiss-Prot
      Q78KK3
      UniProtKB/TrEMBL
      A0A0R4J0P7
      Related
      ENSMUSP00000101537.3, ENSMUST00000105917.3
      Conserved Domains (2) summary
      cd06174
      Location:14378
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:14367
      MFS_1; Major Facilitator Superfamily
    2. NM_008767.3NP_032793.2  solute carrier family 22 member 18

      See identical proteins and their annotated locations for NP_032793.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK002460, BB869719, BE865039, BU758157
      Consensus CDS
      CCDS22041.1
      UniProtKB/Swiss-Prot
      Q78KK3
      UniProtKB/TrEMBL
      A0A0R4J0P7
      Related
      ENSMUSP00000056082.6, ENSMUST00000052348.12
      Conserved Domains (2) summary
      cd06174
      Location:14378
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:14367
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143027463..143053071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508510.3XP_006508573.1  solute carrier family 22 member 18 isoform X1

      See identical proteins and their annotated locations for XP_006508573.1

      Conserved Domains (1) summary
      cd17331
      Location:13396
      MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters
    2. XM_006508514.4XP_006508577.1  solute carrier family 22 member 18 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:1271
      MFS; Major Facilitator Superfamily
    3. XM_006508515.2XP_006508578.1  solute carrier family 22 member 18 isoform X5

      Conserved Domains (1) summary
      cl28910
      Location:1267
      MFS; Major Facilitator Superfamily
    4. XM_006508513.3XP_006508576.1  solute carrier family 22 member 18 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:1279
      MFS; Major Facilitator Superfamily
    5. XM_030242208.1XP_030098068.1  solute carrier family 22 member 18 isoform X6

      Conserved Domains (1) summary
      cl28910
      Location:1259
      MFS; Major Facilitator Superfamily
    6. XM_006508511.3XP_006508574.1  solute carrier family 22 member 18 isoform X1

      See identical proteins and their annotated locations for XP_006508574.1

      Conserved Domains (1) summary
      cd17331
      Location:13396
      MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters
    7. XM_006508512.3XP_006508575.1  solute carrier family 22 member 18 isoform X2

      Conserved Domains (1) summary
      cd17331
      Location:7366
      MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters
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