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    Vpreb3 V-set pre-B cell surrogate light chain 3 [ Mus musculus (house mouse) ]

    Gene ID: 22364, updated on 1-Apr-2024

    Summary

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    Official Symbol
    Vpreb3provided by MGI
    Official Full Name
    V-set pre-B cell surrogate light chain 3provided by MGI
    Primary source
    MGI:MGI:98938
    See related
    Ensembl:ENSMUSG00000000903 AllianceGenome:MGI:98938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8HS-20; Vpreb-3
    Summary
    Predicted to be involved in immune response. Predicted to act upstream of or within negative regulation of immunoglobulin production. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular space. Orthologous to human VPREB3 (V-set pre-B cell surrogate light chain 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 93.8), ovary adult (RPKM 27.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C1; 10 38.63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75778859..75785491)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75943024..75949657)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 11 Neighboring gene STARR-positive B cell enhancer ABC_E8863 Neighboring gene STARR-seq mESC enhancer starr_27166 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene predicted gene 867 Neighboring gene STARR-positive B cell enhancer ABC_E11443 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5150 Neighboring gene predicted gene, 40698 Neighboring gene predicted gene 5134 Neighboring gene STARR-seq mESC enhancer starr_27167 Neighboring gene microRNA 6409

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis in primary B lymphoid precursors following induction of the pre-B cell receptor. Schuh W, et al. Mol Immunol, 2008 Jan. PMID 17681603
    2. Detection of functional V(H)81X heavy chains in adult mice with an assessment of complementarity-determining region 3 diversity and capacity to form pre-B cell receptor. Hayden TA, et al. J Immunol, 2002 Aug 15. PMID 12165522
    3. VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse. Rosnet O, et al. Cytogenet Cell Genet, 1999. PMID 10702669
    4. A novel gene product associated with mu chains in immature B cells. Shirasawa T, et al. EMBO J, 1993 May. PMID 8491176, Free PMC Article
    5. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immunoglobulin production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pre-B lymphocyte protein 3
    Names
    pre-B lymphocyte gene 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358532.2 → NP_001345461.1  pre-B lymphocyte protein 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC134382
      Conserved Domains (1) summary
      cl11960
      Location:16 → 108
      Ig; Immunoglobulin domain

    2. NM_001428879.1 → NP_001415808.1  pre-B lymphocyte protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134382

    3. NM_009514.6 → NP_033540.1  pre-B lymphocyte protein 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033540.1

      Status: VALIDATED

      Source sequence(s)
      AC134382
      Consensus CDS
      CCDS23940.1
      UniProtKB/TrEMBL
      Q61243
      Related
      ENSMUSP00000000926.3, ENSMUST00000000926.3
      Conserved Domains (2) summary
      smart00410
      Location:30 → 115
      IG_like; Immunoglobulin like
      cl11960
      Location:30 → 121
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75778859..75785491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245072.2 → XP_030100932.1  pre-B lymphocyte protein 3 isoform X1

      UniProtKB/TrEMBL
      D3Z6J4
      Related
      ENSMUSP00000113205.2, ENSMUST00000121151.2
      Conserved Domains (1) summary
      cl11960
      Location:37 → 128
      Ig; Immunoglobulin domain

    2. XM_030245073.2 → XP_030100933.1  pre-B lymphocyte protein 3 isoform X2

      Conserved Domains (1) summary
      cl11960
      Location:27 → 115
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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