Fbp1 fructose bisphosphatase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbp1provided by MGI
Official Full Name: fructose bisphosphatase 1provided by MGI
Primary source: MGI:MGI:95492
See related: Ensembl:ENSMUSG00000069805 AllianceGenome:MGI:95492
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbp2; Fbp3; Fbp-2
Summary: Predicted to enable several functions, including cation binding activity; fructose 1,6-bisphosphate 1-phosphatase activity; and identical protein binding activity. Predicted to be involved in several processes, including cellular response to magnesium ion; hexose metabolic process; and regulation of cellular carbohydrate metabolic process. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; facial bone primordium; ganglia; genitourinary system; and liver. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 540.1), kidney adult (RPKM 489.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B3; 13 32.74 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (63012567..63036112, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (62864753..62888298, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1alpha,25(OH)2D3 ameliorates insulin resistance by alleviating gammadelta T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression.
Title: 1α,25(OH)(2)D(3) ameliorates insulin resistance by alleviating γδ T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression.
Hepatic but not Intestinal FBP1 Is Required for Fructose Metabolism and Tolerance.
Title: Hepatic but not Intestinal FBP1 Is Required for Fructose Metabolism and Tolerance.
FBP1 knockdown decreases ovarian cancer formation and cisplatin resistance through EZH2-mediated H3K27me3.
Title: FBP1 knockdown decreases ovarian cancer formation and cisplatin resistance through EZH2-mediated H3K27me3.
Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.
Title: Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation.
FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome.
Title: FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome.
FBP1 triggers dysfunction of natural killer cells by impairing glycolysis and viability.
Title: Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.
The results suggested that the FBP1 signaling pathway may serve an important role in normal follicle growth and hyperandrogenisminduced abnormal development, which may be associated with abnormal glucose metabolism induced by high concentrations of testosterone.
Title: The role of fructose‑1,6‑bisphosphatase 1 in abnormal development of ovarian follicles caused by high testosterone concentration.
The Identification of FBPase interacting partners with mass spectrometry reveals a set of nuclear proteins involved in cell cycle regulation, mRNA processing and in stabilization of genomic DNA structure.
Title: Cell cycle-dependent expression and subcellular localization of fructose 1,6-bisphosphatase.
FBPase plays an important role in regulating glucose sensing and insulin secretion of beta-cells and serves a promising target for diabetes treatment.
Title: Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells.
Data show that NF-kappaB functions downstream of Ras to promote epigenetic downregulation of FBP1.
Title: Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fbp1 (e-PCR), detects polymorphism
- UniSTS:461916

Fbp1 (e-PCR), detects polymorphism
- UniSTS:526037

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AMP binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fructose 1,6-bisphosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose 1,6-bisphosphate 1-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables fructose 1,6-bisphosphate 1-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	ISO Inferred from Sequence Orthology more info
enables monosaccharide binding	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoric ester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to magnesium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in sucrose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fructose-1,6-bisphosphatase 1

Names: D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 3; FBPase liver; fructose-1,6-bisphosphatase isozyme 3; liver FBPase

NP_062268.1

EC 3.1.3.11

XP_011242790.1

EC 3.1.3.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429028.1 → NP_001415957.1 fructose-1,6-bisphosphatase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC156572, AC171004
NM_001429029.1 → NP_001415958.1 fructose-1,6-bisphosphatase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC156572, AC171004
NM_001429030.1 → NP_001415959.1 fructose-1,6-bisphosphatase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC156572, AC171004
NM_019395.4 → NP_062268.1 fructose-1,6-bisphosphatase 1 isoform 1

See identical proteins and their annotated locations for NP_062268.1

Status: VALIDATED

Source sequence(s)

AC156572, AC171004

Consensus CDS

CCDS26590.1

UniProtKB/Swiss-Prot

P97323, Q3UEH1, Q9QXD6

Related

ENSMUSP00000090564.5, ENSMUST00000092888.11

Conserved Domains (1) summary

cd00354
Location:18 → 332

FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

RNA

NR_190570.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC156572, AC171004

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

63012567..63036112 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244488.2 → XP_011242790.1 fructose-1,6-bisphosphatase 1 isoform X1

Conserved Domains (1) summary

cd00354
Location:1 → 248

FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...