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    Scd3 stearoyl-coenzyme A desaturase 3 [ Mus musculus (house mouse) ]

    Gene ID: 30049, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Scd3provided by MGI
    Official Full Name
    stearoyl-coenzyme A desaturase 3provided by MGI
    Primary source
    MGI:MGI:1353437
    See related
    Ensembl:ENSMUSG00000025202 AllianceGenome:MGI:1353437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930513N16Rik
    Summary
    Enables palmitoyl-CoA 9-desaturase activity. Acts upstream of or within monounsaturated fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to several human genes including SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 90.3), mammary gland adult (RPKM 75.0) and 6 other tissues See more
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    Genomic context

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    Location:
    19 C3; 19 37.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44191727..44232455)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44203288..44244016)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene predicted gene, 52383 Neighboring gene STARR-seq mESC enhancer starr_46220 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2 Neighboring gene polycystic kidney disease 2-like 1 Neighboring gene STARR-seq mESC enhancer starr_46221 Neighboring gene STARR-seq mESC enhancer starr_46222 Neighboring gene STARR-positive B cell enhancer mm9_chr19:44341455-44341756 Neighboring gene stearoyl-coenzyme A desaturase pseudogene Neighboring gene predicted gene, 54046 Neighboring gene predicted gene, 35183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel SCD gene and expression of the SCD gene family in mouse skin. Parimoo S, et al. J Investig Dermatol Symp Proc, 1999 Dec. PMID 10674390
    2. Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress. Bond LM, et al. PLoS One, 2018. PMID 30427862, Free PMC Article
    3. UCP1 deficiency increases adipose tissue monounsaturated fatty acid synthesis and trafficking to the liver. Bond LM, et al. J Lipid Res, 2018 Feb. PMID 29203476, Free PMC Article
    4. Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. Dahlhoff M, et al. Development, 2016 May 15. PMID 26989175
    5. Scd3--a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Zheng Y, et al. Genomics, 2001 Jan 15. PMID 11161812

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-CoA 9-desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT enables stearoyl-CoA 9-desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables stearoyl-CoA 9-desaturase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monounsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA desaturase 3
    Names
    delta(9)-desaturase 3
    fatty acid desaturase 3
    palmitoyl-CoA desaturase
    stearoyl-CoA desaturase 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024450.2 → NP_077770.1  acyl-CoA desaturase 3

      See identical proteins and their annotated locations for NP_077770.1

      Status: VALIDATED

      Source sequence(s)
      AC123853, AC125101, AF272037
      Consensus CDS
      CCDS29847.1
      UniProtKB/Swiss-Prot
      Q3UWK5, Q99PL7, Q9D550
      UniProtKB/TrEMBL
      Q8BNZ5
      Related
      ENSMUSP00000026220.6, ENSMUST00000026220.7
      Conserved Domains (2) summary
      cd03505
      Location:97 → 337
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:102 → 306
      FA_desaturase; Fatty acid desaturase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44191727..44232455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PL7.1 GenPept UniProtKB/Swiss-Prot:Q99PL7

    Gene LinkOut

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