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    Itih4 inter alpha-trypsin inhibitor, heavy chain 4 [ Mus musculus (house mouse) ]

    Gene ID: 16427, updated on 23-Jun-2021

    Summary

    Official Symbol
    Itih4provided by MGI
    Official Full Name
    inter alpha-trypsin inhibitor, heavy chain 4provided by MGI
    Primary source
    MGI:MGI:109536
    See related
    Ensembl:ENSMUSG00000021922
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Itih; Itih-4; PK-120; ITI-HC4
    Summary
    This gene encodes a member of the inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors with diverse functions as anti-apoptotic and matrix stabilizing molecules during development. This gene is predominantly expressed in the liver and the encoded protein was found to be a plasma kallikrein-sensitive glycoprotein. This gene is located in a cluster of related inter alpha trypsin inhibitor genes on chromosome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in liver adult (RPKM 412.1), liver E18 (RPKM 232.0) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Itih4 in Genome Data Viewer
    Location:
    14 B; 14 19.09 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30608433..30623943)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30886476..30901986)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (31699678..31715169)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STIM activating enhancer Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables hyaluronic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inter alpha-trypsin inhibitor, heavy chain 4
    Names
    ITI heavy chain H4
    inter-alpha-inhibitor heavy chain 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159299.2NP_001152771.1  inter alpha-trypsin inhibitor, heavy chain 4 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This difference results in a protein (isoform 2) that is 1 amino acid shorter than isoform 1.
      Source sequence(s)
      AK050270, BB809402, BY788238
      Consensus CDS
      CCDS49433.1
      UniProtKB/Swiss-Prot
      A6X935
      UniProtKB/TrEMBL
      E9PVD2
      Related
      ENSMUSP00000077580.6, ENSMUST00000078490.14
      Conserved Domains (3) summary
      smart00609
      Location:19148
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:271452
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:40592
      marine_srt_targ; marine proteobacterial sortase target protein
    2. NM_001289632.1NP_001276561.1  inter alpha-trypsin inhibitor, heavy chain 4 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK050270, BB809402, BY788238
      Consensus CDS
      CCDS70558.1
      UniProtKB/Swiss-Prot
      A6X935
      UniProtKB/TrEMBL
      E9Q5L2
      Related
      ENSMUSP00000125920.2, ENSMUST00000168782.4
      Conserved Domains (3) summary
      smart00609
      Location:19148
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:271452
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:40592
      marine_srt_targ; marine proteobacterial sortase target protein
    3. NM_001289633.1NP_001276562.1  inter alpha-trypsin inhibitor, heavy chain 4 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001276562.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site and lacks an in-frame exon in the 3' coding region, compared to variant 1. This difference results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AK004893, BB809402, BY788238
      Consensus CDS
      CCDS79286.1
      UniProtKB/Swiss-Prot
      A6X935
      Related
      ENSMUSP00000006703.8, ENSMUST00000006703.15
      Conserved Domains (3) summary
      smart00609
      Location:19148
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:271452
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:40592
      marine_srt_targ; marine proteobacterial sortase target protein
    4. NM_018746.4NP_061216.2  inter alpha-trypsin inhibitor, heavy chain 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_061216.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK050270, BB809402, BY788238
      Consensus CDS
      CCDS26901.1
      UniProtKB/Swiss-Prot
      A6X935
      Related
      ENSMUSP00000112798.4, ENSMUST00000120269.11
      Conserved Domains (3) summary
      smart00609
      Location:19148
      VIT; Vault protein Inter-alpha-Trypsin domain
      cd01461
      Location:271452
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:40592
      marine_srt_targ; marine proteobacterial sortase target protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30608433..30623943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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