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    Rap1gap Rap1 GTPase-activating protein [ Mus musculus (house mouse) ]

    Gene ID: 110351, updated on 2-Oct-2021

    Summary

    Official Symbol
    Rap1gapprovided by MGI
    Official Full Name
    Rap1 GTPase-activating proteinprovided by MGI
    Primary source
    MGI:MGI:109338
    See related
    Ensembl:ENSMUSG00000041351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gap; Rap; ARPP-90; Rap1ga1; AI427470; Rap1GAP1; 1300019I11Rik; 2310004O14Rik
    Expression
    Broad expression in adrenal adult (RPKM 86.3), colon adult (RPKM 64.5) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rap1gap in Genome Data Viewer
    Location:
    4 D3; 4 70.02 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137391549..137457172)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (137664711..137729861)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (137237618..137285782)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene predicted gene, 54263 Neighboring gene RAP1 GTPase activating protein, opposite strand Neighboring gene predicted gene, 52682 Neighboring gene alkaline phosphatase, liver/bone/kidney Neighboring gene predicted gene, 32079

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rap1 GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081155.3NP_001074624.1  rap1 GTPase-activating protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK005063, AK019076, AL805954, BE987980, BY249773, BY294932
      Consensus CDS
      CCDS38925.1
      UniProtKB/Swiss-Prot
      A2ALS5
      Related
      ENSMUSP00000042473.6, ENSMUST00000047243.12
      Conserved Domains (2) summary
      smart00390
      Location:6181
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275454
      Rap_GAP; Rap/ran-GAP
    2. NM_001256218.2NP_001243147.1  rap1 GTPase-activating protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two different splice sites in the 3' coding region which shifts the reading frame, compared to variant 1. The resulting protein (isoform 2) has a longer and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AL805954
      Consensus CDS
      CCDS57306.1
      UniProtKB/TrEMBL
      A2ALS4
      Related
      ENSMUSP00000101461.2, ENSMUST00000105835.8
      Conserved Domains (2) summary
      smart00390
      Location:6181
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275454
      Rap_GAP; Rap/ran-GAP
    3. NM_001331215.1NP_001318144.1  rap1 GTPase-activating protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (4) has a shorter, distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK005063, AK019076, AL805954
      Consensus CDS
      CCDS84809.1
      UniProtKB/Swiss-Prot
      A2ALS5
      Related
      ENSMUSP00000095448.5, ENSMUST00000097837.11
    4. NM_001379233.1NP_001366162.1  rap1 GTPase-activating protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL805954
      Conserved Domains (2) summary
      smart00390
      Location:6181
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:275454
      Rap_GAP; Rap/ran-GAP
    5. NM_001379234.1NP_001366163.1  rap1 GTPase-activating protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL805954
      Conserved Domains (2) summary
      smart00390
      Location:2848
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:242421
      Rap_GAP; Rap/ran-GAP
    6. NM_001379235.1NP_001366164.1  rap1 GTPase-activating protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL805954
      Conserved Domains (2) summary
      smart00390
      Location:4969
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:263442
      Rap_GAP; Rap/ran-GAP
    7. NM_001379236.1NP_001366165.1  rap1 GTPase-activating protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL805954
      Conserved Domains (2) summary
      smart00390
      Location:117
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:211390
      Rap_GAP; Rap/ran-GAP
    8. NM_029563.2NP_083839.1  rap1 GTPase-activating protein 1 isoform 3

      See identical proteins and their annotated locations for NP_083839.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AL805954
      UniProtKB/Swiss-Prot
      A2ALS5
      Conserved Domains (2) summary
      pfam02145
      Location:211390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:117
      GoLoco; GoLoco motif

    RNA

    1. NR_138591.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL805954
    2. NR_138592.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) represents use of an alternate promoter, differs in the 5' region, and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK005063, AK019076

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      137391549..137457172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538482.5XP_006538545.1  rap1 GTPase-activating protein 1 isoform X8

      See identical proteins and their annotated locations for XP_006538545.1

      Conserved Domains (2) summary
      pfam02145
      Location:211390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:117
      GoLoco; GoLoco motif
    2. XM_006538483.5XP_006538546.1  rap1 GTPase-activating protein 1 isoform X8

      See identical proteins and their annotated locations for XP_006538546.1

      Conserved Domains (2) summary
      pfam02145
      Location:211390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:117
      GoLoco; GoLoco motif
    3. XM_030253087.2XP_030108947.1  rap1 GTPase-activating protein 1 isoform X9

      Conserved Domains (2) summary
      pfam02145
      Location:211390
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:117
      GoLoco; GoLoco motif
    4. XM_030253084.1XP_030108944.1  rap1 GTPase-activating protein 1 isoform X6

      Conserved Domains (2) summary
      pfam02145
      Location:263442
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:4969
      GoLoco; GoLoco motif
    5. XM_006538475.5XP_006538538.1  rap1 GTPase-activating protein 1 isoform X1

      Conserved Domains (2) summary
      pfam02145
      Location:275454
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:6181
      GoLoco; GoLoco motif
    6. XM_006538478.4XP_006538541.1  rap1 GTPase-activating protein 1 isoform X3

      Conserved Domains (2) summary
      pfam02145
      Location:263442
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:4969
      GoLoco; GoLoco motif
    7. XM_036163582.1XP_036019475.1  rap1 GTPase-activating protein 1 isoform X2

      Conserved Domains (2) summary
      smart00390
      Location:5070
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:264443
      Rap_GAP; Rap/ran-GAP
    8. XM_036163583.1XP_036019476.1  rap1 GTPase-activating protein 1 isoform X4

      Conserved Domains (2) summary
      smart00390
      Location:3858
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:252431
      Rap_GAP; Rap/ran-GAP
    9. XM_036163584.1XP_036019477.1  rap1 GTPase-activating protein 1 isoform X7

      Conserved Domains (2) summary
      smart00390
      Location:3858
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      pfam02145
      Location:252431
      Rap_GAP; Rap/ran-GAP
    10. XM_006538480.2XP_006538543.1  rap1 GTPase-activating protein 1 isoform X5

      Conserved Domains (2) summary
      pfam02145
      Location:242421
      Rap_GAP; Rap/ran-GAP
      pfam02188
      Location:2848
      GoLoco; GoLoco motif

    RNA

    1. XR_003954867.2 RNA Sequence

    2. XR_003954870.2 RNA Sequence

    3. XR_003954866.2 RNA Sequence

    4. XR_003954868.2 RNA Sequence

    5. XR_004941798.1 RNA Sequence

    6. XR_004941796.1 RNA Sequence

    7. XR_004941797.1 RNA Sequence

    8. XR_390722.2 RNA Sequence

    9. XR_390723.4 RNA Sequence

    10. XR_001784080.2 RNA Sequence

    11. XR_001784081.3 RNA Sequence

    12. XR_004941795.1 RNA Sequence

    13. XR_003954869.2 RNA Sequence

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