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    Adgre1 adhesion G protein-coupled receptor E1 [ Mus musculus (house mouse) ]

    Gene ID: 13733, updated on 13-Jul-2021

    Summary

    Official Symbol
    Adgre1provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor E1provided by MGI
    Primary source
    MGI:MGI:106912
    See related
    Ensembl:ENSMUSG00000004730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emr; Ly7; Emr1; Ly71; TM7L; F4/80; DD7A5-; Gpf480; TM7LN3; DD7A5-7; EGF-TM7
    Expression
    Broad expression in spleen adult (RPKM 13.7), mammary gland adult (RPKM 11.5) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Adgre1 in Genome Data Viewer
    Location:
    17 D; 17 29.8 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57665581..57790529)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57358581..57483529)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (57498109..57622952)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52326 Neighboring gene vav 1 oncogene Neighboring gene heat shock protein 8 pseudogene Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene vomeronasal 2, receptor 120 Neighboring gene predicted gene, 54014

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (4) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor E1
    Names
    EGF-like module containing, mucin-like, hormone receptor-like sequence 1
    EGF-like module receptor 1
    EGF-like module-containing mucin-like hormone receptor-like 1
    EMR1 hormone receptor
    cell surface glycoprotein F4/80

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355722.1NP_001342651.1  adhesion G protein-coupled receptor E1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      BC075688, BY197649, BY493080
      Consensus CDS
      CCDS50160.1
      Related
      ENSMUSP00000004850.8, ENSMUST00000004850.8
      Conserved Domains (4) summary
      smart00303
      Location:591640
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:222258
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd15439
      Location:644906
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    2. NM_001355723.1NP_001342652.1  adhesion G protein-coupled receptor E1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK155862, BC075688, BY197649, BY493080
      Conserved Domains (5) summary
      smart00303
      Location:575624
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:117156
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:206242
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam16489
      Location:420549
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15439
      Location:628890
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    3. NM_010130.4NP_034260.1  adhesion G protein-coupled receptor E1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034260.1

      Status: VALIDATED

      Source sequence(s)
      AK133202, BY197649, BY493080
      Consensus CDS
      CCDS50160.1
      UniProtKB/Swiss-Prot
      Q61549
      UniProtKB/TrEMBL
      Q3U9R0
      Related
      ENSMUSP00000083971.6, ENSMUST00000086763.13
      Conserved Domains (4) summary
      smart00303
      Location:591640
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:222258
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd15439
      Location:644906
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57665581..57790529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523602.2XP_006523665.1  adhesion G protein-coupled receptor E1 isoform X2

      Conserved Domains (5) summary
      smart00303
      Location:450499
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:3262
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:81117
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd15439
      Location:503765
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam12662
      Location:151181
      cEGF; Complement Clr-like EGF-like
    2. XM_036160297.1XP_036016190.1  adhesion G protein-coupled receptor E1 isoform X1

      Conserved Domains (4) summary
      smart00303
      Location:552601
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00179
      Location:133172
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:222258
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd15439
      Location:605867
      7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
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