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    Mocs1 molybdenum cofactor synthesis 1 [ Mus musculus (house mouse) ]

    Gene ID: 56738, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mocs1provided by MGI
    Official Full Name
    molybdenum cofactor synthesis 1provided by MGI
    Primary source
    MGI:MGI:1928904
    See related
    Ensembl:ENSMUSG00000064120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI043170; AW536397; 3110045D15Rik
    Expression
    Ubiquitous expression in liver adult (RPKM 48.0), duodenum adult (RPKM 34.1) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mocs1 in Genome Data Viewer
    Location:
    17; 17 C
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (49735378..49762463)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (49428350..49455435)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (49567689..49594755)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L5 pseudogene Neighboring gene predicted gene, 41594 Neighboring gene dishevelled associated activator of morphogenesis 2 Neighboring gene predicted gene, 52301 Neighboring gene kinesin family member 6 Neighboring gene VISTA enhancer mm276

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP 3',8'-cyclase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTP 3',8'-cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclic pyranopterin monophosphate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cyclic pyranopterin monophosphate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of molybdopterin synthase complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    molybdenum cofactor biosynthesis protein 1
    Names
    molybdenum cofactor synthesis-step 1 proteins A and B
    NP_064426.2
    NP_082740.1
    XP_006524743.1
    XP_006524744.1
    XP_006524745.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020042.2NP_064426.2  molybdenum cofactor biosynthesis protein 1 isoform 1

      See identical proteins and their annotated locations for NP_064426.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1, which was also called protein B).
      Source sequence(s)
      AC165258, BE851067, CN701969
      Consensus CDS
      CCDS50143.1
      UniProtKB/Swiss-Prot
      Q5RKZ7
      Related
      ENSMUSP00000133694.2, ENSMUST00000173033.8
      Conserved Domains (4) summary
      cd01335
      Location:74272
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PLN02951
      Location:16384
      PLN02951; Molybderin biosynthesis protein CNX2
      PRK09364
      Location:479635
      moaC; molybdenum cofactor biosynthesis protein MoaC; Provisional
      pfam06463
      Location:241367
      Mob_synth_C; Molybdenum Cofactor Synthesis C
    2. NM_028464.1NP_082740.1  molybdenum cofactor biosynthesis protein 1 isoform 2

      See identical proteins and their annotated locations for NP_082740.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 3' UTR which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2 which was also called protein A) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC165258, BE851067, CN701969
      Consensus CDS
      CCDS57100.1
      UniProtKB/Swiss-Prot
      Q5RKZ7
      Related
      ENSMUSP00000024797.10, ENSMUST00000024797.16
      Conserved Domains (3) summary
      cd01335
      Location:74272
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PLN02951
      Location:16385
      PLN02951; Molybderin biosynthesis protein CNX2
      pfam06463
      Location:241367
      Mob_synth_C; Molybdenum Cofactor Synthesis C

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      49735378..49762463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524680.3XP_006524743.1  molybdenum cofactor biosynthesis protein 1 isoform X1

      Conserved Domains (2) summary
      PLN02951
      Location:1297
      PLN02951; Molybderin biosynthesis protein CNX2
      PRK09364
      Location:392548
      moaC; cyclic pyranopterin monophosphate synthase MoaC
    2. XM_006524681.4XP_006524744.1  molybdenum cofactor biosynthesis protein 1 isoform X2

      Conserved Domains (2) summary
      PLN02951
      Location:1185
      PLN02951; Molybderin biosynthesis protein CNX2
      PRK09364
      Location:280436
      moaC; cyclic pyranopterin monophosphate synthase MoaC
    3. XM_006524682.3XP_006524745.1  molybdenum cofactor biosynthesis protein 1 isoform X3

      Conserved Domains (2) summary
      PLN02951
      Location:1124
      PLN02951; Molybderin biosynthesis protein CNX2
      PRK09364
      Location:219375
      moaC; cyclic pyranopterin monophosphate synthase MoaC
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