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    Trem3 triggering receptor expressed on myeloid cells 3 [ Mus musculus (house mouse) ]

    Gene ID: 58218, updated on 23-Jun-2021

    Summary

    Official Symbol
    Trem3provided by MGI
    Official Full Name
    triggering receptor expressed on myeloid cells 3provided by MGI
    Primary source
    MGI:MGI:1930003
    See related
    Ensembl:ENSMUSG00000041754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TREM-3; BB134760
    Summary
    The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and is thought to function as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells. [provided by RefSeq, Jan 2013]
    Expression
    Biased expression in liver E18 (RPKM 5.6), liver E14 (RPKM 1.2) and 3 other tissues See more
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    Genomic context

    See Trem3 in Genome Data Viewer
    Location:
    17; 17 C
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48554707..48565876)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48247677..48258848)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48386944..48398207)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530064D06 gene Neighboring gene predicted gene, 52308 Neighboring gene triggering receptor expressed on myeloid cells 1 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells-like 4 Neighboring gene triggering receptor expressed on myeloid cells-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables lipoteichoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    triggering receptor expressed on myeloid cells 3
    Names
    triggering receptor expressed on monocytes 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021407.3NP_067382.1  triggering receptor expressed on myeloid cells 3 precursor

      See identical proteins and their annotated locations for NP_067382.1

      Status: REVIEWED

      Source sequence(s)
      AC241601, AK079407, BY594056
      Consensus CDS
      CCDS28861.1
      UniProtKB/TrEMBL
      Q9JKE1
      Related
      ENSMUSP00000044478.6, ENSMUST00000048065.6
      Conserved Domains (1) summary
      cl11960
      Location:30112
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48554707..48565876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317592.3XP_017173081.1  triggering receptor expressed on myeloid cells 3 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:370
      Ig; Immunoglobulin domain
    2. XM_006524731.3XP_006524794.1  triggering receptor expressed on myeloid cells 3 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:370
      Ig; Immunoglobulin domain
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