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    Hexb hexosaminidase B [ Mus musculus (house mouse) ]

    Gene ID: 15212, updated on 22-Aug-2021

    Summary

    Official Symbol
    Hexbprovided by MGI
    Official Full Name
    hexosaminidase Bprovided by MGI
    Primary source
    MGI:MGI:96074
    See related
    Ensembl:ENSMUSG00000021665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in colon adult (RPKM 103.1), genital fat pad adult (RPKM 82.6) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Hexb in Genome Data Viewer
    Location:
    13 D1; 13 50.66 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (97312839..97334865, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (97176331..97198357, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (97946286..97968312, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169, member A Neighboring gene proteolipid protein 2 pseudogene Neighboring gene NSA2 ribosome biogenesis homolog Neighboring gene G elongation factor, mitochondrial 2 Neighboring gene ectodermal-neural cortex 1 Neighboring gene predicted gene, 33390

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-galactosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-N-acetylglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-N-acetylhexosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables beta-N-acetylhexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-N-acetylhexosaminidase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables beta-N-acetylhexosaminidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables beta-N-acetylhexosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hexosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ganglioside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ganglioside catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ganglioside catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycosaminoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within glycosaminoglycan metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glycosphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid storage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lysosome organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myelination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within oligosaccharide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within penetration of zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cellular metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within sexual reproduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in single fertilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cortical granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    beta-hexosaminidase subunit beta
    Names
    N-acetyl-beta-glucosaminidase subunit beta
    beta-N-acetylhexosaminidase subunit beta
    hexosaminidase subunit B
    NP_034552.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010422.2NP_034552.1  beta-hexosaminidase subunit beta precursor

      See identical proteins and their annotated locations for NP_034552.1

      Status: VALIDATED

      Source sequence(s)
      AK168825, BY145642, CD775639
      Consensus CDS
      CCDS26709.1
      UniProtKB/Swiss-Prot
      P20060
      UniProtKB/TrEMBL
      Q3TXR9
      Related
      ENSMUSP00000022169.8, ENSMUST00000022169.10
      Conserved Domains (2) summary
      cd06562
      Location:179519
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:35157
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      97312839..97334865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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