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    Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 15160, updated on 23-Jun-2021

    Summary

    Official Symbol
    Serpind1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade D, member 1provided by MGI
    Primary source
    MGI:MGI:96051
    See related
    Ensembl:ENSMUSG00000022766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HC; HCII; Hcf2; HC-II; AA985900; AI303446
    Expression
    Biased expression in liver adult (RPKM 147.0), liver E18 (RPKM 126.4) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Serpind1 in Genome Data Viewer
    Location:
    16 A3; 16 10.74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17149235..17161438)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17331371..17343574)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (17331464..17343665)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene hypermethylated in cancer 2 Neighboring gene transmembrane protein 191C Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene predicted gene, 24927 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene synaptosomal-associated protein 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC107662

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    heparin cofactor 2
    Names
    heparin cofactor II
    protease inhibitor leuserpin-2
    serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
    serpin D1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331047.1NP_001317976.1  heparin cofactor 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR comared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC110573, AI195091, BY770136, CJ238471
      Consensus CDS
      CCDS28000.1
      UniProtKB/Swiss-Prot
      P49182
      Related
      ENSMUSP00000156303.2, ENSMUST00000231884.2
      Conserved Domains (1) summary
      cd02047
      Location:43476
      HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...
    2. NM_008223.4NP_032249.3  heparin cofactor 2 precursor

      See identical proteins and their annotated locations for NP_032249.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA253694, AC110573, AI195091, AI196697, AI529123, AI529613, CJ067925, CJ238471
      Consensus CDS
      CCDS28000.1
      UniProtKB/Swiss-Prot
      P49182
      Related
      ENSMUSP00000023450.7, ENSMUST00000023450.15
      Conserved Domains (1) summary
      cd02047
      Location:43476
      HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17149235..17161438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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