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    Apobec2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 [ Mus musculus (house mouse) ]

    Gene ID: 11811, updated on 23-Jun-2021

    Summary

    Official Symbol
    Apobec2provided by MGI
    Official Full Name
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2provided by MGI
    Primary source
    MGI:MGI:1343178
    See related
    Ensembl:ENSMUSG00000040694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp1
    Expression
    Biased expression in heart adult (RPKM 62.8), mammary gland adult (RPKM 42.7) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Apobec2 in Genome Data Viewer
    Location:
    17 C; 17 24.02 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48726259..48739756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48419231..48432728, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48558556..48572053, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene nuclear transcription factor-Y alpha Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene predicted gene, 30283 Neighboring gene VISTA enhancer mm243 Neighboring gene translocator protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytidine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA demethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytidine to uridine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cytidine to uridine editing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cytidine to uridine editing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within mRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    C->U-editing enzyme APOBEC-2
    Names
    apolipoprotein B editing complex 2
    mRNA(cytosine(6666)) deaminase 2
    probable C->U-editing enzyme APOBEC-2
    NP_033824.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009694.3NP_033824.1  C->U-editing enzyme APOBEC-2

      See identical proteins and their annotated locations for NP_033824.1

      Status: VALIDATED

      Source sequence(s)
      AC165291, AC166164
      Consensus CDS
      CCDS28868.1
      UniProtKB/Swiss-Prot
      Q9WV35
      Related
      ENSMUSP00000047402.4, ENSMUST00000046549.5
      Conserved Domains (3) summary
      cd01283
      Location:61151
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:160208
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:52221
      APOBEC_N; APOBEC-like N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48726259..48739756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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