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    Itgb2 integrin beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 16414, updated on 5-Jul-2021

    Summary

    Official Symbol
    Itgb2provided by MGI
    Official Full Name
    integrin beta 2provided by MGI
    Primary source
    MGI:MGI:96611
    See related
    Ensembl:ENSMUSG00000000290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2E6; LAD; Cd18; Lfa1; MF17; LCAMB; AI528527
    Expression
    Biased expression in thymus adult (RPKM 72.3), spleen adult (RPKM 63.3) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Itgb2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77366164..77401542)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77530329..77565708)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (76993093..77028419)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 207, member A Neighboring gene RIKEN cDNA 2810425M01 gene Neighboring gene predicted gene, 36040 Neighboring gene pituitary tumor-transforming 1 interacting protein Neighboring gene small ubiquitin-like modifier 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (5) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ICAM-3 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables amyloid-beta binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to cargo receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement component C3b binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular extravasation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to low-density lipoprotein particle stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukocyte migration involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neutrophil degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    colocalizes_with cytoplasmic region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin alphaL-beta2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphaM-beta2 complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin beta-2
    Names
    Mac-1 beta
    cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
    complement receptor C3 subunit beta
    lymphocyte function associated antigen 1
    macrophage antigen-1 beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008404.5NP_032430.2  integrin beta-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032430.2

      Status: VALIDATED

      Source sequence(s)
      AC153830
      Consensus CDS
      CCDS23956.1
      UniProtKB/Swiss-Prot
      P11835
      UniProtKB/TrEMBL
      Q542I8
      Related
      ENSMUSP00000000299.8, ENSMUST00000000299.14
      Conserved Domains (3) summary
      pfam00362
      Location:32447
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:626700
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:727767
      Integrin_b_cyt; Integrin beta cytoplasmic domain

    RNA

    1. NR_157228.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK161236, AK169587, BY787094
      Related
      ENSMUST00000156644.8
    2. NR_157229.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153830, AK161236, BY787094
      Related
      ENSMUST00000153541.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77366164..77401542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513272.4XP_006513335.1  integrin beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006513335.1

      Conserved Domains (4) summary
      smart00187
      Location:15369
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:548622
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:649689
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam18372
      Location:369398
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
    2. XM_006513271.4XP_006513334.1  integrin beta-2 isoform X1

      See identical proteins and their annotated locations for XP_006513334.1

      Conserved Domains (4) summary
      smart00187
      Location:15369
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:548622
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:649689
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam18372
      Location:369398
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
    3. XM_017313814.2XP_017169303.1  integrin beta-2 isoform X1

      Conserved Domains (4) summary
      smart00187
      Location:15369
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:548622
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:649689
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam18372
      Location:369398
      I-EGF_1; Integrin beta epidermal growth factor like domain 1
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