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    Scd1 stearoyl-Coenzyme A desaturase 1 [ Mus musculus (house mouse) ]

    Gene ID: 20249, updated on 19-Jul-2021

    Summary

    Official Symbol
    Scd1provided by MGI
    Official Full Name
    stearoyl-Coenzyme A desaturase 1provided by MGI
    Primary source
    MGI:MGI:98239
    See related
    Ensembl:ENSMUSG00000037071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SC; ab; Scd; Scd-; Scd-1; AA589638; AI265570
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 3754.4), mammary gland adult (RPKM 3202.4) and 5 other tissues See more
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    Genomic context

    See Scd1 in Genome Data Viewer
    Location:
    19 C3; 19 37.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44382889..44396148, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44394450..44407709, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44468940..44482199, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene stearoyl-Coenzyme A desaturase 2 Neighboring gene microRNA 5114 Neighboring gene stearoyl-coenzyme A desaturase 4 Neighboring gene predicted gene, 35406 Neighboring gene wingless-type MMTV integration site family, member 8B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol esterification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monounsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within monounsaturated fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in monounsaturated fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cholesterol esterification TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of water loss via skin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sebaceous gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sterol esterification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tarsal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in unsaturated fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within white fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acyl-CoA desaturase 1
    Names
    asebia
    delta(9)-desaturase 1
    fatty acid desaturase 1
    stearoyl-CoA desaturase 1
    NP_033153.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009127.4NP_033153.2  acyl-CoA desaturase 1

      See identical proteins and their annotated locations for NP_033153.2

      Status: VALIDATED

      Source sequence(s)
      AA881780, AK012370, AK148103, BQ885468, BU053011, CD544724
      Consensus CDS
      CCDS29850.1
      UniProtKB/Swiss-Prot
      P13516
      UniProtKB/TrEMBL
      Q547C4
      Related
      ENSMUSP00000036936.3, ENSMUST00000041331.4
      Conserved Domains (2) summary
      cd03505
      Location:93333
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:98301
      FA_desaturase; Fatty acid desaturase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44382889..44396148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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