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    Ephb2 Eph receptor B2 [ Mus musculus (house mouse) ]

    Gene ID: 13844, updated on 19-Sep-2021

    Summary

    Official Symbol
    Ephb2provided by MGI
    Official Full Name
    Eph receptor B2provided by MGI
    Primary source
    MGI:MGI:99611
    See related
    Ensembl:ENSMUSG00000028664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dr; Er; Nu; Drt; Erk; Nuk; Prk; Sek; Tyr; Cek5; Hek5; Qek5; Sek3; ETECK; Prkm5; Tyro5
    Summary
    This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors consist of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. The encoded receptor preferentially binds membrane-bound ephrin-B ligands and is involved in nervous system and vascular development. This gene is used as a marker of intestinal stem cells. Homozygous knockout mice for this gene exhibit impaired axon guidance and vestibular function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in whole brain E14.5 (RPKM 18.7), CNS E14 (RPKM 13.6) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ephb2 in Genome Data Viewer
    Location:
    4 D3; 4 69.0 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136374850..136563637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136647536..136836326, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (136209523..136391850, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene testis expressed 46 Neighboring gene lactamase, beta-like 1 Neighboring gene VISTA enhancer mm1494 Neighboring gene predicted gene, 52708 Neighboring gene predicted gene, 31536 Neighboring gene complement component 1, q subcomponent, beta polypeptide Neighboring gene complement component 1, q subcomponent, C chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables axon guidance receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane-ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane-ephrin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in central nervous system projection neuron axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in commissural neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendritic spine morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hindbrain tangential cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning or memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of NMDA glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection retraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within optic nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NMDA glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic membrane assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of T-helper 17 type immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of body fluid levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synapse assembly EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retinal ganglion cell axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in urogenital system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle-mediated intercellular transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in integral component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in integral component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synapse NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ephrin type-B receptor 2
    Names
    neural kinase
    nuk receptor tyrosine kinase
    tyrosine-protein kinase receptor EPH-3
    tyrosine-protein kinase receptor SEK-3
    NP_001277682.1
    NP_034272.1
    XP_006538594.1
    XP_006538596.1
    XP_006538597.1
    XP_030109050.1
    XP_030109051.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290753.2NP_001277682.1  ephrin type-B receptor 2 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL671173, BC062924, CJ180821
      Consensus CDS
      CCDS71498.1
      UniProtKB/Swiss-Prot
      P54763
      Related
      ENSMUSP00000058135.8, ENSMUST00000059287.14
      Conserved Domains (5) summary
      cd05065
      Location:617885
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:911981
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437520
      fn3; Fibronectin type III domain
      pfam14575
      Location:549617
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. NM_010142.4NP_034272.1  ephrin type-B receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_034272.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AL671173, BC043088, CJ180821
      Consensus CDS
      CCDS18809.1
      UniProtKB/Swiss-Prot
      P54763
      Related
      ENSMUSP00000101471.3, ENSMUST00000105845.9
      Conserved Domains (5) summary
      cd05065
      Location:616884
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:910980
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437519
      fn3; Fibronectin type III domain
      pfam14575
      Location:548616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136374850..136563637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538534.4XP_006538597.1  ephrin type-B receptor 2 isoform X1

      Conserved Domains (5) summary
      cd05065
      Location:618886
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:912982
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437520
      fn3; Fibronectin type III domain
      pfam14575
      Location:549618
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. XM_030253190.2XP_030109050.1  ephrin type-B receptor 2 isoform X3

      Conserved Domains (5) summary
      cd05065
      Location:595863
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:889959
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:1173
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:414497
      fn3; Fibronectin type III domain
      pfam14575
      Location:526595
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    3. XM_030253191.2XP_030109051.1  ephrin type-B receptor 2 isoform X5

      Conserved Domains (5) summary
      cd05065
      Location:585853
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:879949
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:326419
      fn3; Fibronectin type III domain
      pfam14575
      Location:517585
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    4. XM_006538533.5XP_006538596.1  ephrin type-B receptor 2 isoform X4

      Conserved Domains (5) summary
      cd05065
      Location:586854
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:880950
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:326419
      fn3; Fibronectin type III domain
      pfam14575
      Location:517586
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    5. XM_006538531.5XP_006538594.1  ephrin type-B receptor 2 isoform X2

      UniProtKB/Swiss-Prot
      P54763
      Related
      ENSMUSP00000101472.3, ENSMUST00000105846.9
      Conserved Domains (5) summary
      cd05065
      Location:617885
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09552
      Location:911981
      SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
      cd10477
      Location:19196
      EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
      pfam00041
      Location:437519
      fn3; Fibronectin type III domain
      pfam14575
      Location:548617
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
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