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    Dnmbp dynamin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 71972, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dnmbpprovided by MGI
    Official Full Name
    dynamin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1917352
    See related
    Ensembl:ENSMUSG00000025195 AllianceGenome:MGI:1917352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TUBA; 2410003L07Rik; 2410003M15Rik
    Summary
    This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in colon adult (RPKM 15.1), large intestine adult (RPKM 10.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnmbp in Genome Data Viewer
    Location:
    19 C3; 19 36.67 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43835259..43930930, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43846815..43940232, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family member 2 Neighboring gene STARR-seq mESC enhancer starr_46204 Neighboring gene predicted gene 10768 Neighboring gene predicted gene, 24400 Neighboring gene STARR-seq mESC enhancer starr_46211 Neighboring gene RIKEN cDNA 4933403J19 gene Neighboring gene carboxypeptidase N, polypeptide 1 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of protrusion formation during cell-to-cell spread of Listeria. Ireton K, et al. Front Cell Infect Microbiol, 2014. PMID 24600591, Free PMC Article
    2. The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria. Rajabian T, et al. Nat Cell Biol, 2009 Oct. PMID 19767742, Free PMC Article
    3. Impact of the Listeria monocytogenes protein InlC on infection in mice. Leung N, et al. Infect Immun, 2013 Apr. PMID 23403554, Free PMC Article
    4. Tricellulin regulates junctional tension of epithelial cells at tricellular contacts through Cdc42. Oda Y, et al. J Cell Sci, 2014 Oct 1. PMID 25097232
    5. Tuba stimulates intracellular N-WASP-dependent actin assembly. Kovacs EM, et al. J Cell Sci, 2006 Jul 1. PMID 16757518

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynamin-binding protein
    Names
    scaffold protein Tuba

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306088.2 → NP_001293017.1  dynamin-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001293017.1

      Status: VALIDATED

      Source sequence(s)
      AC132251
      Consensus CDS
      CCDS84442.1
      UniProtKB/TrEMBL
      A0A1D5RLL6
      Related
      ENSMUSP00000148421.2, ENSMUST00000212592.2
      Conserved Domains (4) summary
      cd07589
      Location:263 → 454
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11798
      Location:535 → 591
      SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd12141
      Location:763 → 819
      SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
      cd00160
      Location:31 → 211
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    2. NM_001403290.1 → NP_001390219.1  dynamin-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132251
      UniProtKB/TrEMBL
      A0A1D5RMB5
      Related
      ENSMUSP00000148708.2, ENSMUST00000212032.2

    3. NM_001403291.1 → NP_001390220.1  dynamin-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132251
      UniProtKB/TrEMBL
      A0A1D5RMB5

    4. NM_001403292.1 → NP_001390221.1  dynamin-binding protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132251

    5. NM_001403293.1 → NP_001390222.1  dynamin-binding protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC132251

    6. NM_001403294.1 → NP_001390223.1  dynamin-binding protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC132251

    7. NM_001403295.1 → NP_001390224.1  dynamin-binding protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC132251
      Related
      ENSMUSP00000148546.2, ENSMUST00000212048.2

    8. NM_001403296.1 → NP_001390225.1  dynamin-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132251
      UniProtKB/TrEMBL
      A0A1D5RLL6

    9. NM_001403297.1 → NP_001390226.1  dynamin-binding protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC132251

    10. NM_028029.5 → NP_082305.1  dynamin-binding protein isoform 1

      See identical proteins and their annotated locations for NP_082305.1

      Status: VALIDATED

      Source sequence(s)
      AC132251
      Consensus CDS
      CCDS29839.1
      UniProtKB/Swiss-Prot
      Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2
      UniProtKB/TrEMBL
      A0A0R4J055
      Related
      ENSMUSP00000148582.2, ENSMUST00000212396.2
      Conserved Domains (8) summary
      cd07589
      Location:1020 → 1211
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11794
      Location:7 → 56
      SH3_DNMBP_N1; First N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11795
      Location:70 → 124
      SH3_DNMBP_N2; Second N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11796
      Location:150 → 200
      SH3_DNMBP_N3; Third N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11798
      Location:1292 → 1348
      SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd12141
      Location:1520 → 1576
      SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
      pfam00621
      Location:787 → 969
      RhoGEF; RhoGEF domain
      cl17036
      Location:248 → 297
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43835259..43930930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TXD4.2 GenPept UniProtKB/Swiss-Prot:Q6TXD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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