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    Cdc42 cell division cycle 42 [ Mus musculus (house mouse) ]

    Gene ID: 12540, updated on 16-Oct-2021

    Summary

    Official Symbol
    Cdc42provided by MGI
    Official Full Name
    cell division cycle 42provided by MGI
    Primary source
    MGI:MGI:106211
    See related
    Ensembl:ENSMUSG00000006699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI747189; AU018915
    Expression
    Ubiquitous expression in CNS E18 (RPKM 107.5), placenta adult (RPKM 89.1) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cdc42 in Genome Data Viewer
    Location:
    4 D3; 4 69.83 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137047007..137085070, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (137319696..137357759, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (136875611..136913652, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31820 Neighboring gene chromobox homolog 5 pseudogene Neighboring gene wingless-type MMTV integration site family, member 4 Neighboring gene ribosomal protein L31, pseudogene 10 Neighboring gene predicted gene, 52681

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GBD domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT enables Rho GDP-dissociation inhibitor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Rho GDP-dissociation inhibitor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables apolipoprotein A-I receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Cdc42 protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament branching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac conduction system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell-cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within dendritic cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endosomal transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endothelin receptor signaling pathway involved in heart process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of Golgi localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within heart contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modification of synaptic structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in modification of synaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuron fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuropilin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nucleus localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of pinocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synapse structural plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of modification of postsynaptic structure ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral RNA genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in leading edge membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in storage vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cell division control protein 42 homolog
    Names
    G25K GTP-binding protein
    cell division cycle 42 homolog
    NP_001230698.1
    NP_033991.1
    XP_030108999.1
    XP_030109000.1
    XP_030109001.1
    XP_030109002.1
    XP_036019511.1
    XP_036019512.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243769.1NP_001230698.1  cell division control protein 42 homolog isoform 2

      See identical proteins and their annotated locations for NP_001230698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which is the same length but has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL645468, BF467211, CD353254, CD551112, L78075
      Consensus CDS
      CCDS57305.1
      UniProtKB/Swiss-Prot
      P60766
      Related
      ENSMUSP00000030417.10, ENSMUST00000030417.10
      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    2. NM_009861.3NP_033991.1  cell division control protein 42 homolog isoform 1

      See identical proteins and their annotated locations for NP_033991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AK168758, AL645468, BE685696, CD551112
      Consensus CDS
      CCDS18816.1
      UniProtKB/Swiss-Prot
      P60766
      Related
      ENSMUSP00000054634.7, ENSMUST00000051477.13
      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      137047007..137085070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253140.2XP_030109000.1  cell division control protein 42 homolog isoform X1

      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    2. XM_030253142.1XP_030109002.1  cell division control protein 42 homolog isoform X2

      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    3. XM_030253139.2XP_030108999.1  cell division control protein 42 homolog isoform X1

      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    4. XM_030253141.2XP_030109001.1  cell division control protein 42 homolog isoform X2

      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    5. XM_036163618.1XP_036019511.1  cell division control protein 42 homolog isoform X1

      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    6. XM_036163619.1XP_036019512.1  cell division control protein 42 homolog isoform X2

      Conserved Domains (1) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
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