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    Lrp12 low density lipoprotein-related protein 12 [ Mus musculus (house mouse) ]

    Gene ID: 239393, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lrp12provided by MGI
    Official Full Name
    low density lipoprotein-related protein 12provided by MGI
    Primary source
    MGI:MGI:2443132
    See related
    Ensembl:ENSMUSG00000022305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LRP-12; AI848829; C820005L12Rik
    Expression
    Broad expression in CNS E14 (RPKM 8.6), whole brain E14.5 (RPKM 7.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lrp12 in Genome Data Viewer
    Location:
    15; 15 B3.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (39733985..39807417, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (39870589..39944015, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (39702149..39775303, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase Neighboring gene predicted gene 16291 Neighboring gene predicted gene, 53879 Neighboring gene expressed sequence AU022793 Neighboring gene predicted gene, 33251

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    low-density lipoprotein receptor-related protein 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347036.2NP_001333965.1  low-density lipoprotein receptor-related protein 12 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      BC039793, BC058345
      Consensus CDS
      CCDS84168.1
      UniProtKB/Swiss-Prot
      Q8BUJ9
      Related
      ENSMUSP00000105934.3, ENSMUST00000110305.3
    2. NM_172814.4NP_766402.1  low-density lipoprotein receptor-related protein 12 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766402.1

      Status: VALIDATED

      Source sequence(s)
      AC101945, AC158567
      Consensus CDS
      CCDS27446.1
      UniProtKB/Swiss-Prot
      Q8BUJ9
      Related
      ENSMUSP00000022916.6, ENSMUST00000022916.13
      Conserved Domains (2) summary
      cd00041
      Location:56158
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:451485
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      39733985..39807417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520903.5XP_006520966.1  low-density lipoprotein receptor-related protein 12 isoform X2

      Conserved Domains (3) summary
      cd00041
      Location:249353
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:433467
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00431
      Location:28137
      CUB; CUB domain
    2. XM_006520902.4XP_006520965.1  low-density lipoprotein receptor-related protein 12 isoform X1

      Conserved Domains (3) summary
      cd00041
      Location:268372
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:452486
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00431
      Location:47156
      CUB; CUB domain
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