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    Trem1 triggering receptor expressed on myeloid cells 1 [ Mus musculus (house mouse) ]

    Gene ID: 58217, updated on 8-Jul-2021

    Summary

    Official Symbol
    Trem1provided by MGI
    Official Full Name
    triggering receptor expressed on myeloid cells 1provided by MGI
    Primary source
    MGI:MGI:1930005
    See related
    Ensembl:ENSMUSG00000042265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Biased expression in testis adult (RPKM 1.2), liver E18 (RPKM 1.1) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Trem1 in Genome Data Viewer
    Location:
    17; 17 C
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48539763..48553955)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48232713..48246927)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48371922..48386091)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9830107B12 gene Neighboring gene RIKEN cDNA A530064D06 gene Neighboring gene predicted gene, 52308 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells 3 Neighboring gene triggering receptor expressed on myeloid cells-like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chemokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within chemokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cytokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cytokine production involved in immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil extravasation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neutrophil-mediated killing of gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    triggering receptor expressed on myeloid cells 1
    Names
    triggering receptor expressed in monocytes 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347399.1NP_001334328.1  triggering receptor expressed on myeloid cells 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC241601
      Consensus CDS
      CCDS84319.1
      UniProtKB/TrEMBL
      Q14DT9
      Related
      ENSMUSP00000108877.4, ENSMUST00000113251.10
    2. NM_021406.5NP_067381.1  triggering receptor expressed on myeloid cells 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_067381.1

      Status: VALIDATED

      Source sequence(s)
      AC241601, AK089439
      Consensus CDS
      CCDS28860.1
      UniProtKB/Swiss-Prot
      Q9JKE2
      Related
      ENSMUSP00000038636.7, ENSMUST00000048782.7
      Conserved Domains (2) summary
      smart00410
      Location:32133
      IG_like; Immunoglobulin like
      pfam07686
      Location:32134
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48539763..48553955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524729.5XP_006524792.1  triggering receptor expressed on myeloid cells 1 isoform X3

      Conserved Domains (1) summary
      pfam07686
      Location:32134
      V-set; Immunoglobulin V-set domain
    2. XM_036160714.1XP_036016607.1  triggering receptor expressed on myeloid cells 1 isoform X1

      Conserved Domains (2) summary
      cd00096
      Location:2833
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:25132
      Ig; Immunoglobulin domain
    3. XM_006524728.4XP_006524791.1  triggering receptor expressed on myeloid cells 1 isoform X2

      See identical proteins and their annotated locations for XP_006524791.1

      Conserved Domains (1) summary
      pfam07686
      Location:189
      V-set; Immunoglobulin V-set domain
    4. XM_006524726.5XP_006524789.1  triggering receptor expressed on myeloid cells 1 isoform X2

      See identical proteins and their annotated locations for XP_006524789.1

      Conserved Domains (1) summary
      pfam07686
      Location:189
      V-set; Immunoglobulin V-set domain
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