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    Zranb3 zinc finger, RAN-binding domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 226409, updated on 6-May-2021

    Summary

    Official Symbol
    Zranb3provided by MGI
    Official Full Name
    zinc finger, RAN-binding domain containing 3provided by MGI
    Primary source
    MGI:MGI:1918362
    See related
    Ensembl:ENSMUSG00000036086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AH2; AI316834; C730006D09; 4933425L19Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 1.7), limb E14.5 (RPKM 1.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zranb3 in Genome Data Viewer
    Location:
    1; 1 E3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (127881916..128030799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (127954179..128103053, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (129850763..129998985, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene RAB3 GTPase activating protein subunit 1 Neighboring gene predicted gene 28800 Neighboring gene My020 protein Neighboring gene ribosomal protein L28, pseudogene 1 Neighboring gene male-enhanced antigen 1 pseudogene Neighboring gene R3H domain containing 1 Neighboring gene microRNA 128-1

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables annealing helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA rewinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork protection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in replication fork protection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA annealing helicase and endonuclease ZRANB3
    Names
    annealing helicase 2
    zinc finger Ran-binding domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285945.1NP_001272874.1  DNA annealing helicase and endonuclease ZRANB3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131995, AK016921, BC066035
      UniProtKB/Swiss-Prot
      Q6NZP1
      UniProtKB/TrEMBL
      Q9D3Z7
      Conserved Domains (6) summary
      smart00547
      Location:625647
      ZnF_RBZ; Zinc finger domain
      smart00487
      Location:33216
      DEXDc; DEAD-like helicases superfamily
      cd00046
      Location:59194
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00085
      Location:9781043
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:625644
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00271
      Location:334439
      Helicase_C; Helicase conserved C-terminal domain
    2. NM_001357573.1NP_001344502.1  DNA annealing helicase and endonuclease ZRANB3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC129545, AC131995
      Consensus CDS
      CCDS35697.1
      Related
      ENSMUSP00000108157.3, ENSMUST00000112538.4
      Conserved Domains (4) summary
      smart00547
      Location:621643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:9741039
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    3. NM_027678.3NP_081954.1  DNA annealing helicase and endonuclease ZRANB3 isoform 1

      See identical proteins and their annotated locations for NP_081954.1

      Status: VALIDATED

      Source sequence(s)
      AC129545, AC131995, AK084943, BC066035
      Consensus CDS
      CCDS35697.1
      UniProtKB/Swiss-Prot
      Q6NZP1
      UniProtKB/TrEMBL
      Q8BUI4
      Related
      ENSMUSP00000083806.6, ENSMUST00000086614.12
      Conserved Domains (4) summary
      smart00547
      Location:621643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:9741039
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      127881916..128030799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529408.2XP_006529471.1  DNA annealing helicase and endonuclease ZRANB3 isoform X1

      Conserved Domains (5) summary
      smart00547
      Location:625647
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:11481
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:10251090
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:625644
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:41260
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
    2. XM_036163815.1XP_036019708.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

      Conserved Domains (5) summary
      smart00547
      Location:561583
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:1417
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:9611026
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:561580
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:1196
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
    3. XM_006529411.5XP_006529474.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

      See identical proteins and their annotated locations for XP_006529474.1

      Conserved Domains (5) summary
      smart00547
      Location:621643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:10211086
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:37256
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
    4. XM_006529410.2XP_006529473.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

      See identical proteins and their annotated locations for XP_006529473.1

      Conserved Domains (5) summary
      smart00547
      Location:621643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:10211086
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:37256
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
    5. XM_036163817.1XP_036019710.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

      Conserved Domains (5) summary
      smart00547
      Location:561583
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:1417
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:9611026
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:561580
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:1196
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
    6. XM_030253114.1XP_030108974.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

      Conserved Domains (5) summary
      smart00547
      Location:561583
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:1417
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:9611026
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:561580
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:1196
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
    7. XM_006529409.1XP_006529472.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

      See identical proteins and their annotated locations for XP_006529472.1

      Conserved Domains (5) summary
      smart00547
      Location:621643
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:7477
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:10211086
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:621640
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:37256
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
    8. XM_030253115.1XP_030108975.1  DNA annealing helicase and endonuclease ZRANB3 isoform X4

      Conserved Domains (5) summary
      smart00547
      Location:561583
      ZnF_RBZ; Zinc finger domain
      COG0553
      Location:1417
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd00085
      Location:914979
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:561580
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18010
      Location:1196
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1
    9. XM_036163819.1XP_036019712.1  DNA annealing helicase and endonuclease ZRANB3 isoform X5

      Conserved Domains (4) summary
      smart00547
      Location:290312
      ZnF_RBZ; Zinc finger domain
      cd00085
      Location:690755
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
      sd00029
      Location:290309
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd18793
      Location:9115
      SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
    10. XM_006529416.3XP_006529479.1  DNA annealing helicase and endonuclease ZRANB3 isoform X6

      See identical proteins and their annotated locations for XP_006529479.1

      UniProtKB/TrEMBL
      Q9D3Z7
      Conserved Domains (2) summary
      COG0553
      Location:11481
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18010
      Location:41260
      DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

    RNA

    1. XR_001784077.2 RNA Sequence

    2. XR_004941832.1 RNA Sequence

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