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    Pgc progastricsin (pepsinogen C) [ Mus musculus (house mouse) ]

    Gene ID: 109820, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pgcprovided by MGI
    Official Full Name
    progastricsin (pepsinogen C)provided by MGI
    Primary source
    MGI:MGI:98909
    See related
    Ensembl:ENSMUSG00000023987
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Upg; Upg-; Upg1; Upg-1; 2210410L06Rik
    Expression
    Restricted expression toward duodenum adult (RPKM 123.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pgc in Genome Data Viewer
    Location:
    17 C; 17 23.98 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48037767..48045403)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47726842..47734478)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (47863791..47871427)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand Neighboring gene predicted gene, 46579 Neighboring gene transcription factor EB Neighboring gene MyoD family inhibitor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117575

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of antibacterial peptide production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gastricsin
    Names
    pepsinogen C
    urinary pepsinogen 1
    NP_080249.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025973.3NP_080249.2  gastricsin precursor

      See identical proteins and their annotated locations for NP_080249.2

      Status: PROVISIONAL

      Source sequence(s)
      AK008959
      Consensus CDS
      CCDS28855.1
      UniProtKB/Swiss-Prot
      Q9D7R7
      Related
      ENSMUSP00000024782.6, ENSMUST00000024782.12
      Conserved Domains (3) summary
      pfam00026
      Location:75390
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:1846
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:73391
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48037767..48045403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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