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    Htr1d 5-hydroxytryptamine (serotonin) receptor 1D [ Mus musculus (house mouse) ]

    Gene ID: 15552, updated on 16-Oct-2021

    Summary

    Official Symbol
    Htr1dprovided by MGI
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 1Dprovided by MGI
    Primary source
    MGI:MGI:96276
    See related
    Ensembl:ENSMUSG00000070687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5-HT1D; Gpcr14; Htr1db; 5-HT-1D; AI853647
    Expression
    Biased expression in ovary adult (RPKM 1.0), bladder adult (RPKM 0.8) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Htr1d in Genome Data Viewer
    Location:
    4 D3; 4 68.74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136150829..136176284)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136423522..136444405)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (135979439..136000317)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295 Neighboring gene leucine zipper protein 1 Neighboring gene lysine (K)-specific demethylase 1A Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene testis expressed 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serotonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serotonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 1D
    Names
    5-hydroxytryptamine (serotonin) receptor 1D beta
    G-protein coupled receptor 14
    serotonin receptor 1D

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285482.1NP_001272411.1  5-hydroxytryptamine receptor 1D

      See identical proteins and their annotated locations for NP_001272411.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 all encode the same protein.
      Source sequence(s)
      AI853647, AK082016, AL670673, AW487918, BY728591
      Consensus CDS
      CCDS18806.1
      UniProtKB/Swiss-Prot
      Q61224
      Related
      ENSMUSP00000112402.2, ENSMUST00000121571.8
      Conserved Domains (2) summary
      cd14964
      Location:3862
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32364
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_001285483.1NP_001272412.1  5-hydroxytryptamine receptor 1D

      See identical proteins and their annotated locations for NP_001272412.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
      Source sequence(s)
      AI853647, AK082016, AL670673, AW487918
      Consensus CDS
      CCDS18806.1
      UniProtKB/Swiss-Prot
      Q61224
      Related
      ENSMUSP00000112840.2, ENSMUST00000117699.2
      Conserved Domains (2) summary
      cd14964
      Location:3862
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32364
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. NM_001285484.1NP_001272413.1  5-hydroxytryptamine receptor 1D

      See identical proteins and their annotated locations for NP_001272413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
      Source sequence(s)
      AI853647, AK082016, AL670673, AW487918
      Consensus CDS
      CCDS18806.1
      UniProtKB/Swiss-Prot
      Q61224
      Conserved Domains (2) summary
      cd14964
      Location:3862
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32364
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    4. NM_008309.5NP_032335.2  5-hydroxytryptamine receptor 1D

      See identical proteins and their annotated locations for NP_032335.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
      Source sequence(s)
      AI853647, AK082016, AW487918, BY728591
      Consensus CDS
      CCDS18806.1
      UniProtKB/Swiss-Prot
      Q61224
      Related
      ENSMUSP00000086052.5, ENSMUST00000088677.5
      Conserved Domains (2) summary
      cd14964
      Location:3862
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32364
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      136150829..136176284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538578.3XP_006538641.1  5-hydroxytryptamine receptor 1D isoform X1

      See identical proteins and their annotated locations for XP_006538641.1

      UniProtKB/Swiss-Prot
      Q61224
      Conserved Domains (2) summary
      cd14964
      Location:3862
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32364
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_017319986.3XP_017175475.1  5-hydroxytryptamine receptor 1D isoform X1

      UniProtKB/Swiss-Prot
      Q61224
      Conserved Domains (2) summary
      cd14964
      Location:3862
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32364
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_006538577.4XP_006538640.1  5-hydroxytryptamine receptor 1D isoform X1

      See identical proteins and their annotated locations for XP_006538640.1

      UniProtKB/Swiss-Prot
      Q61224
      Conserved Domains (2) summary
      cd14964
      Location:3862
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:32364
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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