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    Lgmn legumain [ Mus musculus (house mouse) ]

    Gene ID: 19141, updated on 13-Jul-2021

    Summary

    Official Symbol
    Lgmnprovided by MGI
    Official Full Name
    legumainprovided by MGI
    Primary source
    MGI:MGI:1330838
    See related
    Ensembl:ENSMUSG00000021190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Pr; AEP; Prsc1; AI746452; AU022324
    Summary
    This gene encodes a member of the cysteine peptidase family C13 that plays an important role in the endosome/lysosomal degradation system. The encoded inactive preproprotein undergoes autocatalytic removal of the C-terminal inhibitory propeptide to generate the active endopeptidase that cleaves protein substrates on the C-terminal side of asparagine residues. Mice lacking the encoded protein exhibit defects in the lysosomal processing of proteins resulting in their accumulation in the lysosomes, and develop symptoms resembling hemophagocytic lymphohistiocytosis. [provided by RefSeq, Aug 2016]
    Expression
    Broad expression in kidney adult (RPKM 276.6), placenta adult (RPKM 128.8) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Lgmn in Genome Data Viewer
    Location:
    12; 12 E
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102360341..102405987, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102394082..102439728, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (103632308..103677907, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene Ras and Rab interactor 3 Neighboring gene predicted gene, 30198 Neighboring gene golgi autoantigen, golgin subfamily a, 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hepatocyte growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic spine organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in memory IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of ERBB signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis involved in cellular protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis involved in cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in self proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vacuolar protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    legumain
    Names
    asparaginyl endopeptidase
    preprolegumain
    protease, cysteine, 1
    NP_001365804.1
    NP_035305.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378875.1NP_001365804.1  legumain preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC122302
      Related
      ENSMUSP00000105647.2, ENSMUST00000110020.8
      Conserved Domains (2) summary
      pfam01650
      Location:31287
      Peptidase_C13; Peptidase C13 family
      cd21115
      Location:311431
      legumain_C; C-terminal prodomain of legumain
    2. NM_011175.4NP_035305.1  legumain preproprotein

      See identical proteins and their annotated locations for NP_035305.1

      Status: REVIEWED

      Source sequence(s)
      AC122302
      Consensus CDS
      CCDS26119.1
      UniProtKB/Swiss-Prot
      O89017
      UniProtKB/TrEMBL
      A2RTI3, Q3UE99
      Related
      ENSMUSP00000021607.9, ENSMUST00000021607.9
      Conserved Domains (2) summary
      pfam01650
      Location:31287
      Peptidase_C13; Peptidase C13 family
      cd21115
      Location:311431
      legumain_C; C-terminal prodomain of legumain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102360341..102405987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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