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    Pld3 phospholipase D family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 18807, updated on 8-Jul-2021

    Summary

    Official Symbol
    Pld3provided by MGI
    Official Full Name
    phospholipase D family, member 3provided by MGI
    Primary source
    MGI:MGI:1333782
    See related
    Ensembl:ENSMUSG00000003363
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sam; Sam-9
    Expression
    Ubiquitous expression in cortex adult (RPKM 194.3), frontal lobe adult (RPKM 152.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pld3 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27230843..27252663, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27531367..27553229, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (28317037..28338131, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15541 Neighboring gene periaxin Neighboring gene homeodomain interacting protein kinase 4 Neighboring gene RIKEN cDNA 2310022A10 gene Neighboring gene predicted gene, 45975 Neighboring gene ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4) 
    • Endonuclease-mediated (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables phospholipase D activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase D activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables phospholipase D activity TAS
    Traceable Author Statement
    more info
     
    enables single-stranded DNA 5'-3' exodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded DNA 5'-3' exodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    5'-3' exonuclease PLD3
    Names
    PLD 3
    choline phosphatase 3
    phosphatidylcholine-hydrolyzing phospholipase D3
    phospholipase D3
    schwannoma-associated protein 9
    NP_001304284.1
    NP_035246.1
    XP_006539705.1
    XP_006539706.1
    XP_006539708.1
    XP_006539709.1
    XP_011248758.1
    XP_017177531.1
    XP_030098079.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317355.1NP_001304284.1  5'-3' exonuclease PLD3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158304, BC068170, BC076586, BY318971
      Consensus CDS
      CCDS21025.1
      UniProtKB/Swiss-Prot
      O35405
      Related
      ENSMUSP00000112942.2, ENSMUST00000117611.8
      Conserved Domains (1) summary
      PHA02820
      Location:77488
      PHA02820; phospholipase-D-like protein; Provisional
    2. NM_011116.2NP_035246.1  5'-3' exonuclease PLD3

      See identical proteins and their annotated locations for NP_035246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158304, BC068170, BY318971, CK624966
      Consensus CDS
      CCDS21025.1
      UniProtKB/Swiss-Prot
      O35405
      Related
      ENSMUSP00000113820.2, ENSMUST00000117095.8
      Conserved Domains (1) summary
      PHA02820
      Location:77488
      PHA02820; phospholipase-D-like protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27230843..27252663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539646.4XP_006539709.1  5'-3' exonuclease PLD3 isoform X3

      See identical proteins and their annotated locations for XP_006539709.1

      Conserved Domains (1) summary
      PHA02820
      Location:11417
      PHA02820; phospholipase-D-like protein; Provisional
    2. XM_006539643.4XP_006539706.1  5'-3' exonuclease PLD3 isoform X1

      See identical proteins and their annotated locations for XP_006539706.1

      UniProtKB/Swiss-Prot
      O35405
      Conserved Domains (1) summary
      PHA02820
      Location:77488
      PHA02820; phospholipase-D-like protein; Provisional
    3. XM_006539642.4XP_006539705.1  5'-3' exonuclease PLD3 isoform X1

      See identical proteins and their annotated locations for XP_006539705.1

      UniProtKB/Swiss-Prot
      O35405
      Conserved Domains (1) summary
      PHA02820
      Location:77488
      PHA02820; phospholipase-D-like protein; Provisional
    4. XM_011250456.3XP_011248758.1  5'-3' exonuclease PLD3 isoform X3

      See identical proteins and their annotated locations for XP_011248758.1

      Conserved Domains (1) summary
      PHA02820
      Location:11417
      PHA02820; phospholipase-D-like protein; Provisional
    5. XM_017322042.3XP_017177531.1  5'-3' exonuclease PLD3 isoform X2

      Conserved Domains (1) summary
      PHA02820
      Location:24435
      PHA02820; phospholipase-D-like protein; Provisional
    6. XM_030242219.2XP_030098079.1  5'-3' exonuclease PLD3 isoform X3

      Conserved Domains (1) summary
      PHA02820
      Location:11417
      PHA02820; phospholipase-D-like protein; Provisional
    7. XM_006539645.4XP_006539708.1  5'-3' exonuclease PLD3 isoform X3

      See identical proteins and their annotated locations for XP_006539708.1

      Conserved Domains (1) summary
      PHA02820
      Location:11417
      PHA02820; phospholipase-D-like protein; Provisional
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