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    Treml1 triggering receptor expressed on myeloid cells-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 71326, updated on 23-Jun-2021

    Summary

    Official Symbol
    Treml1provided by MGI
    Official Full Name
    triggering receptor expressed on myeloid cells-like 1provided by MGI
    Primary source
    MGI:MGI:1918576
    See related
    Ensembl:ENSMUSG00000023993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TLT-; TLT-1; 5430401J17Rik
    Expression
    Biased expression in spleen adult (RPKM 13.6), liver E14.5 (RPKM 10.2) and 6 other tissues See more
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    Genomic context

    See Treml1 in Genome Data Viewer
    Location:
    17; 17 C
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48666944..48674204)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48359916..48367176)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48499241..48506471)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B430306N03 gene Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene nuclear transcription factor-Y alpha Neighboring gene O-acyl-ADP-ribose deacylase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in platelet activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within platelet activation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in wound healing NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    trem-like transcript 1 protein
    Names
    triggering receptor expressed on myeloid cells-like 1c
    triggering receptor expressed on myeloid cells-like 1d
    triggering receptor expressed on myeloid cells-like 1e
    triggering receptor expressed on myeloid cells-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289451.1NP_001276380.1  trem-like transcript 1 protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001276380.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites in the coding region, which result in a frameshift, compared to variant 1. This results in an isoform (2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI553593, AK017256, DQ087183
      Consensus CDS
      CCDS89115.1
      UniProtKB/Swiss-Prot
      Q8K558
      UniProtKB/TrEMBL
      A6XA75
      Related
      ENSMUSP00000153104.2, ENSMUST00000225849.2
      Conserved Domains (1) summary
      cl11960
      Location:26108
      Ig; Immunoglobulin domain
    2. NM_001289457.1NP_001276386.1  trem-like transcript 1 protein isoform 3 precursor

      See identical proteins and their annotated locations for NP_001276386.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in an isoform (3) that is shorter, compared to isoform 1.
      Source sequence(s)
      AI553593, AK017256, AY078502
      Consensus CDS
      CCDS89114.1
      UniProtKB/Swiss-Prot
      Q8K558
      Related
      ENSMUSP00000024792.8, ENSMUST00000024792.8
      Conserved Domains (1) summary
      cl11960
      Location:26108
      Ig; Immunoglobulin domain
    3. NM_027763.2NP_082039.1  trem-like transcript 1 protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_082039.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI553593, AK079428, AY078502
      Consensus CDS
      CCDS28866.1
      UniProtKB/Swiss-Prot
      Q8K558
      Related
      ENSMUSP00000153300.2, ENSMUST00000224001.2
      Conserved Domains (1) summary
      cl11960
      Location:26108
      Ig; Immunoglobulin domain

    RNA

    1. NR_110338.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses multiple alternate splice sites, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AI553593, AK017256, DQ087181
      Related
      ENSMUST00000223956.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48666944..48674204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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