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    Sema4g sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G [ Mus musculus (house mouse) ]

    Gene ID: 26456, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Sema4gprovided by MGI
    Official Full Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Gprovided by MGI
    Primary source
    MGI:MGI:1347047
    See related
    Ensembl:ENSMUSG00000025207 AllianceGenome:MGI:1347047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including generation of neurons; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gut; liver; nervous system; sensory organ; and urinary system. Orthologous to human SEMA4G (semaphorin 4G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 249.8), liver adult (RPKM 161.1) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sema4g in Genome Data Viewer
    Location:
    19 C3; 19 38.16 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44976838..44991836)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44988743..45003397)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene predicted gene, 25482 Neighboring gene RIKEN cDNA 4930414N06 gene Neighboring gene STARR-positive B cell enhancer ABC_E9998 Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper, putative tumor suppressor 2 Neighboring gene PDZ domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization and expression of sema4g, a novel member of the semaphorin gene family. Li H, et al. Mech Dev, 1999 Sep. PMID 10495281
    2. Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair. Xia J, et al. Dev Cell, 2015 May 4. PMID 25892012
    3. An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration. Azzarelli R, et al. Nat Commun, 2014 Feb 27. PMID 24572910, Free PMC Article
    4. Balance between BDNF and Semaphorins gates the innervation of the mammary gland. Sar Shalom H, et al. Elife, 2019 Jan 10. PMID 30628891, Free PMC Article
    5. Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development. Maier V, et al. Mol Cell Neurosci, 2011 Feb. PMID 21122816, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We have identified here Sema4C and Sema4G as candidate ligands for Plexin-B2
      Title: Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    semaphorin-4G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413627.1 → NP_001400556.1  semaphorin-4G precursor

      Status: VALIDATED

      Source sequence(s)
      AC132957
      UniProtKB/Swiss-Prot
      Q9WUH7

    2. NM_011976.2 → NP_036106.1  semaphorin-4G precursor

      See identical proteins and their annotated locations for NP_036106.1

      Status: VALIDATED

      Source sequence(s)
      AC132957
      Consensus CDS
      CCDS29853.1
      UniProtKB/Swiss-Prot
      Q9WUH7
      Related
      ENSMUSP00000026225.9, ENSMUST00000026225.15
      Conserved Domains (3) summary
      pfam01437
      Location:505 → 555
      PSI; Plexin repeat
      cd05872
      Location:565 → 648
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:47 → 504
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44976838..44991836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161601.1 → XP_036017494.1  semaphorin-4G isoform X1

      UniProtKB/Swiss-Prot
      Q9WUH7
      Conserved Domains (3) summary
      pfam01437
      Location:505 → 555
      PSI; Plexin repeat
      cd05872
      Location:565 → 648
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:47 → 504
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    2. XM_036161603.1 → XP_036017496.1  semaphorin-4G isoform X2

      Conserved Domains (3) summary
      pfam01437
      Location:237 → 287
      PSI; Plexin repeat
      cd05872
      Location:297 → 380
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:2 → 236
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    3. XM_036161604.1 → XP_036017497.1  semaphorin-4G isoform X2

      Conserved Domains (3) summary
      pfam01437
      Location:237 → 287
      PSI; Plexin repeat
      cd05872
      Location:297 → 380
      Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
      cl15693
      Location:2 → 236
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RNA

    1. XR_386476.4 RNA Sequence

    2. XR_386479.2 RNA Sequence

    3. XR_004940150.1 RNA Sequence

    4. XR_003952792.2 RNA Sequence

    5. XR_386477.3 RNA Sequence

    6. XR_004940151.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUH7.1 GenPept UniProtKB/Swiss-Prot:Q9WUH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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