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    Canx calnexin [ Mus musculus (house mouse) ]

    Gene ID: 12330, updated on 8-Nov-2021

    Summary

    Official Symbol
    Canxprovided by MGI
    Official Full Name
    calnexinprovided by MGI
    Primary source
    MGI:MGI:88261
    See related
    Ensembl:ENSMUSG00000020368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cnx; AI988026; D11Ertd153e; 1110069N15Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 118.8), CNS E11.5 (RPKM 79.3) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Canx in Genome Data Viewer
    Location:
    11 B1.3; 11 30.46 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50184784..50216500, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50293957..50325673, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (50107459..50139175, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene leukotriene C4 synthase Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene predicted gene, 46280 Neighboring gene predicted gene, 31865 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum quality control compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110499.1NP_001103969.1  calnexin precursor

      See identical proteins and their annotated locations for NP_001103969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004422, AK017254, AK084175, AK166649, BB857984, BX632165, BY309447
      Consensus CDS
      CCDS24633.1
      UniProtKB/Swiss-Prot
      P35564
      UniProtKB/TrEMBL
      Q5SUC3
      Related
      ENSMUSP00000137440.2, ENSMUST00000179865.8
      Conserved Domains (1) summary
      pfam00262
      Location:72441
      Calreticulin; Calreticulin family
    2. NM_001110500.1NP_001103970.1  calnexin precursor

      See identical proteins and their annotated locations for NP_001103970.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004422, AK017254, AK028279, AK165508, BX632165, BY309447
      Consensus CDS
      CCDS24633.1
      UniProtKB/Swiss-Prot
      P35564
      UniProtKB/TrEMBL
      Q5SUC3
      Conserved Domains (1) summary
      pfam00262
      Location:72441
      Calreticulin; Calreticulin family
    3. NM_007597.3NP_031623.1  calnexin precursor

      See identical proteins and their annotated locations for NP_031623.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK004422, AK017254, AK084175, AK166649, BX632165, BY309447
      Consensus CDS
      CCDS24633.1
      UniProtKB/Swiss-Prot
      P35564
      UniProtKB/TrEMBL
      Q5SUC3
      Related
      ENSMUSP00000020637.9, ENSMUST00000020637.9
      Conserved Domains (1) summary
      pfam00262
      Location:72441
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50184784..50216500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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