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    Cpe carboxypeptidase E [ Mus musculus (house mouse) ]

    Gene ID: 12876, updated on 22-Aug-2021

    Summary

    Official Symbol
    Cpeprovided by MGI
    Official Full Name
    carboxypeptidase Eprovided by MGI
    Primary source
    MGI:MGI:101932
    See related
    Ensembl:ENSMUSG00000037852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CP; CPH; fat; Cph-; Cph1; NF-a; Cph-1; R74677; NF-alpha1
    Summary
    This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in frontal lobe adult (RPKM 416.8), cortex adult (RPKM 400.4) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Cpe in Genome Data Viewer
    Location:
    8 B3.1; 8 32.3 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (65045576..65146143, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (64592542..64693109, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (67071339..67171837, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35521 Neighboring gene microRNA 710 Neighboring gene methylsterol monoxygenase 1 Neighboring gene kelch-like 2, Mayven Neighboring gene predicted gene, 46040

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7101

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cobalt ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurexin family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac left ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in enkephalin processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within insulin processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptide hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to secretory granule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dense core granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    carboxypeptidase E
    Names
    carboxypeptidase H
    enkephalin convertase
    prohormone-processing carboxypeptidase
    NP_038522.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013494.4NP_038522.2  carboxypeptidase E preproprotein

      See identical proteins and their annotated locations for NP_038522.2

      Status: REVIEWED

      Source sequence(s)
      AK047891, BE849320, CX241703
      Consensus CDS
      CCDS22327.1
      UniProtKB/Swiss-Prot
      Q00493
      UniProtKB/TrEMBL
      Q543R4
      Related
      ENSMUSP00000048555.8, ENSMUST00000048967.9
      Conserved Domains (2) summary
      cd11308
      Location:375449
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cl11393
      Location:49371
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      65045576..65146143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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