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    Pon1 paraoxonase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18979, updated on 6-May-2021

    Summary

    Official Symbol
    Pon1provided by MGI
    Official Full Name
    paraoxonase 1provided by MGI
    Primary source
    MGI:MGI:103295
    See related
    Ensembl:ENSMUSG00000002588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pon
    Expression
    Biased expression in liver adult (RPKM 147.4), liver E18 (RPKM 50.7) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pon1 in Genome Data Viewer
    Location:
    6 A1; 6 1.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5168090..5193987, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5168090..5193987, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (5118090..5143946, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 9A Neighboring gene predicted gene, 52886 Neighboring gene predicted gene, 46949 Neighboring gene paraoxonase 3 Neighboring gene paraoxonase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-L-homoserine-lactone lactonohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aryldialkylphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aryldialkylphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables arylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables arylesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables arylesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-density lipoprotein particle binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spherical high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serum paraoxonase/arylesterase 1
    Names
    A-esterase 1
    PON 1
    aromatic esterase 1
    serum aryldialkylphosphatase 1
    NP_035264.2
    XP_006505074.1
    XP_011239351.1
    XP_030111082.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011134.3NP_035264.2  serum paraoxonase/arylesterase 1 precursor

      See identical proteins and their annotated locations for NP_035264.2

      Status: VALIDATED

      Source sequence(s)
      AC074225, AI194741, BB870662, U32684
      Consensus CDS
      CCDS19898.1
      UniProtKB/Swiss-Prot
      P52430
      Related
      ENSMUSP00000002663.6, ENSMUST00000002663.12
      Conserved Domains (1) summary
      pfam01731
      Location:168253
      Arylesterase; Arylesterase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      5168090..5193987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505011.2XP_006505074.1  serum paraoxonase/arylesterase 1 isoform X2

      See identical proteins and their annotated locations for XP_006505074.1

      Related
      ENSMUSP00000135195.3, ENSMUST00000177159.9
      Conserved Domains (1) summary
      cl22863
      Location:159186
      Str_synth; Strictosidine synthase
    2. XM_030255222.1XP_030111082.1  serum paraoxonase/arylesterase 1 isoform X3

      Conserved Domains (1) summary
      cl22863
      Location:159186
      Str_synth; Strictosidine synthase
    3. XM_011241049.1XP_011239351.1  serum paraoxonase/arylesterase 1 isoform X1

      Conserved Domains (1) summary
      pfam01731
      Location:168253
      Arylesterase
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