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    Fcna ficolin A [ Mus musculus (house mouse) ]

    Gene ID: 14133, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fcnaprovided by MGI
    Official Full Name
    ficolin Aprovided by MGI
    Primary source
    MGI:MGI:1340905
    See related
    Ensembl:ENSMUSG00000026938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fcn; Fcn1
    Expression
    Biased expression in liver E18 (RPKM 38.4), spleen adult (RPKM 36.2) and 10 other tissues See more
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    Genomic context

    See Fcna in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25514677..25525448, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25624665..25635440, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (25480187..25483494, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 183 Neighboring gene ficolin A, opposite strand Neighboring gene transmembrane protein 141 Neighboring gene predicted gene, 35630 Neighboring gene lipocalin 15 Neighboring gene lipocalin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables antigen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate derivative binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbohydrate derivative binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mannan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sialic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in complement activation, lectin pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within complement activation, lectin pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ficolin-1
    Names
    M-ficolin
    collagen/fibrinogen domain-containing protein 1
    ficolin-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007995.3NP_032021.1  ficolin-1 precursor

      See identical proteins and their annotated locations for NP_032021.1

      Status: VALIDATED

      Source sequence(s)
      AK133539, AV290365, BB582883
      Consensus CDS
      CCDS15785.1
      UniProtKB/Swiss-Prot
      O70165
      UniProtKB/TrEMBL
      Q4FJM1
      Related
      ENSMUSP00000028307.9, ENSMUST00000028307.9
      Conserved Domains (2) summary
      pfam01391
      Location:65106
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:123332
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25514677..25525448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239016.4XP_011237318.1  ficolin-1 isoform X1

      See identical proteins and their annotated locations for XP_011237318.1

      UniProtKB/Swiss-Prot
      O70165
      UniProtKB/TrEMBL
      Q4FJM1
      Conserved Domains (2) summary
      pfam01391
      Location:65106
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:123332
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    2. XM_006497673.5XP_006497736.1  ficolin-1 isoform X1

      See identical proteins and their annotated locations for XP_006497736.1

      UniProtKB/Swiss-Prot
      O70165
      UniProtKB/TrEMBL
      Q4FJM1
      Conserved Domains (2) summary
      pfam01391
      Location:65106
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:123332
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    3. XM_006497675.4XP_006497738.1  ficolin-1 isoform X2

      Conserved Domains (2) summary
      pfam01391
      Location:6594
      Collagen; Collagen triple helix repeat (20 copies)
      cd00087
      Location:111320
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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