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    Dnase2b deoxyribonuclease II beta [ Mus musculus (house mouse) ]

    Gene ID: 56629, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dnase2bprovided by MGI
    Official Full Name
    deoxyribonuclease II betaprovided by MGI
    Primary source
    MGI:MGI:1913283
    See related
    Ensembl:ENSMUSG00000028185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dl; Dna; Dlad; AI526873; DnaseIIb
    Expression
    Biased expression in liver E18 (RPKM 1.3), liver adult (RPKM 0.9) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Dnase2b in Genome Data Viewer
    Location:
    3; 3 H2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146275488..146322815, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146569733..146617060, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (146244337..146278562, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 Neighboring gene ribosome production factor 1 homolog Neighboring gene urate oxidase Neighboring gene predicted gene 16325 Neighboring gene sterile alpha motif domain containing 13 Neighboring gene predicted gene, 40169

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables deoxyribonuclease II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables deoxyribonuclease II activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    deoxyribonuclease-2-beta
    Names
    DNase II beta
    DNase II-like acid DNase
    DNase2-like acid DNase
    deoxyribonuclease DLAD
    endonuclease DLAD
    NP_064341.3
    XP_006501826.1
    XP_006501827.1
    XP_011238473.1
    XP_011238474.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019957.4NP_064341.3  deoxyribonuclease-2-beta precursor

      See identical proteins and their annotated locations for NP_064341.3

      Status: VALIDATED

      Source sequence(s)
      AK079224, BC075661
      Consensus CDS
      CCDS17904.1
      UniProtKB/Swiss-Prot
      Q9QY48
      Related
      ENSMUSP00000142872.2, ENSMUST00000200633.2
      Conserved Domains (1) summary
      pfam03265
      Location:29342
      DNase_II; Deoxyribonuclease II

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      146275488..146322815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240172.2XP_011238474.1  deoxyribonuclease-2-beta isoform X1

      See identical proteins and their annotated locations for XP_011238474.1

      UniProtKB/Swiss-Prot
      Q9QY48
      Conserved Domains (1) summary
      pfam03265
      Location:29342
      DNase_II; Deoxyribonuclease II
    2. XM_011240171.2XP_011238473.1  deoxyribonuclease-2-beta isoform X1

      See identical proteins and their annotated locations for XP_011238473.1

      UniProtKB/Swiss-Prot
      Q9QY48
      Conserved Domains (1) summary
      pfam03265
      Location:29342
      DNase_II; Deoxyribonuclease II
    3. XM_006501764.4XP_006501827.1  deoxyribonuclease-2-beta isoform X1

      See identical proteins and their annotated locations for XP_006501827.1

      UniProtKB/Swiss-Prot
      Q9QY48
      Related
      ENSMUSP00000029836.5, ENSMUST00000029836.9
      Conserved Domains (1) summary
      pfam03265
      Location:29342
      DNase_II; Deoxyribonuclease II
    4. XM_006501763.4XP_006501826.1  deoxyribonuclease-2-beta isoform X1

      See identical proteins and their annotated locations for XP_006501826.1

      UniProtKB/Swiss-Prot
      Q9QY48
      Conserved Domains (1) summary
      pfam03265
      Location:29342
      DNase_II; Deoxyribonuclease II

    RNA

    1. XR_867221.2 RNA Sequence

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