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    Chil3 chitinase-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 12655, updated on 6-May-2021

    Summary

    Official Symbol
    Chil3provided by MGI
    Official Full Name
    chitinase-like 3provided by MGI
    Primary source
    MGI:MGI:1330860
    See related
    Ensembl:ENSMUSG00000040809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ym1; Chi3; ECF-L; Chi3l3; AI505981
    Summary
    The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is thought to function as a lectin and may be involved in inflammation and allergy. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in lung adult (RPKM 97.4) and liver E18 (RPKM 36.9) See more
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    Genomic context

    See Chil3 in Genome Data Viewer
    Location:
    3 F2.2; 3 46.49 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106054870..106074880, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106147554..106167564, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (105950472..105970482, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene chitinase, acidic 1 Neighboring gene chitinase-like 4 Neighboring gene chitinase 3-like 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-galactosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-N-acetylhexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carbohydrate binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT enables chitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chitinase-like protein 3
    Names
    beta-N-acetylhexosaminidase Ym1
    eosinophil chemotactic cytokine
    eosinophil chemotactic factor-L
    secreted protein Ym1
    NP_034022.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009892.3NP_034022.2  chitinase-like protein 3 precursor

      See identical proteins and their annotated locations for NP_034022.2

      Status: REVIEWED

      Source sequence(s)
      AC125461, AK137503
      Consensus CDS
      CCDS17718.1
      UniProtKB/Swiss-Prot
      O35744
      Related
      ENSMUSP00000053923.9, ENSMUST00000063062.9
      Conserved Domains (2) summary
      cd02872
      Location:24387
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:26365
      Glyco_18; Glyco_18 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      106054870..106074880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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