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    Mov10 Mov10 RISC complex RNA helicase [ Mus musculus (house mouse) ]

    Gene ID: 17454, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mov10provided by MGI
    Official Full Name
    Mov10 RISC complex RNA helicaseprovided by MGI
    Primary source
    MGI:MGI:97054
    See related
    Ensembl:ENSMUSG00000002227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mov-; C77703; Mov-10
    Expression
    Ubiquitous expression in duodenum adult (RPKM 17.0), small intestine adult (RPKM 14.9) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mov10 in Genome Data Viewer
    Location:
    3; 3 F2.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104702144..104725935, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104794828..104818619, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (104597750..104621481, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1J Neighboring gene ras homolog family member C Neighboring gene capping protein (actin filament) muscle Z-line, alpha 1 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene ribosomal protein S27 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-3' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    putative helicase MOV-10
    Names
    moloney leukemia virus 10 protein
    NP_001156912.1
    NP_001156913.1
    NP_032645.2
    XP_006501163.1
    XP_006501164.1
    XP_030108314.1
    XP_030108315.1
    XP_036018811.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163440.1NP_001156912.1  putative helicase MOV-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK159295, BC053743
      Consensus CDS
      CCDS51033.1
      UniProtKB/Swiss-Prot
      P23249
      UniProtKB/TrEMBL
      E9PW39
      Related
      ENSMUSP00000126897.2, ENSMUST00000166979.8
      Conserved Domains (3) summary
      pfam13086
      Location:574765
      AAA_11; AAA domain
      pfam13087
      Location:772996
      AAA_12; AAA domain
      cl21455
      Location:574761
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001163441.1NP_001156913.1  putative helicase MOV-10 isoform b

      See identical proteins and their annotated locations for NP_001156913.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK150204, BC053743, BY302921
      Consensus CDS
      CCDS38579.1
      UniProtKB/Swiss-Prot
      P23249
      UniProtKB/TrEMBL
      Q3UD86
      Related
      ENSMUSP00000128246.2, ENSMUST00000168015.8
      Conserved Domains (2) summary
      cd18808
      Location:735940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    3. NM_008619.2NP_032645.2  putative helicase MOV-10 isoform b

      See identical proteins and their annotated locations for NP_032645.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform.
      Source sequence(s)
      BC053743, BY302921
      Consensus CDS
      CCDS38579.1
      UniProtKB/Swiss-Prot
      P23249
      Related
      ENSMUSP00000002297.6, ENSMUST00000002297.12
      Conserved Domains (2) summary
      cd18808
      Location:735940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104702144..104725935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252455.1XP_030108315.1  putative helicase MOV-10 isoform X2

      Conserved Domains (2) summary
      cd18808
      Location:679884
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:443678
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    2. XM_036162918.1XP_036018811.1  putative helicase MOV-10 isoform X2

      Conserved Domains (2) summary
      cd18808
      Location:679884
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:443678
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    3. XM_006501100.1XP_006501163.1  putative helicase MOV-10 isoform X1

      See identical proteins and their annotated locations for XP_006501163.1

      UniProtKB/Swiss-Prot
      P23249
      Conserved Domains (2) summary
      cd18808
      Location:735940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    4. XM_030252454.2XP_030108314.1  putative helicase MOV-10 isoform X2

      Conserved Domains (2) summary
      cd18808
      Location:679884
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:443678
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase
    5. XM_006501101.4XP_006501164.1  putative helicase MOV-10 isoform X1

      See identical proteins and their annotated locations for XP_006501164.1

      UniProtKB/Swiss-Prot
      P23249
      Conserved Domains (2) summary
      cd18808
      Location:735940
      SF1_C_Upf1; C-terminal helicase domain of Upf1-like family helicases
      cd18038
      Location:499734
      DEXXQc_Helz-like; DEXXQ/H-box helicase domain of Helz-like helicase

    RNA

    1. XR_375493.4 RNA Sequence

      Related
      ENSMUST00000106774.8
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