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    Ago2 argonaute RISC catalytic subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 239528, updated on 9-Aug-2021

    Summary

    Official Symbol
    Ago2provided by MGI
    Official Full Name
    argonaute RISC catalytic subunit 2provided by MGI
    Primary source
    MGI:MGI:2446632
    See related
    Ensembl:ENSMUSG00000036698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eif2c; Eif2c2; Gerp95; Gm10365; AI225898; AL022874; AW546247; mKIAA4215; 1110029L17Rik; 2310051F07Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 19.6), spleen adult (RPKM 13.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ago2 in Genome Data Viewer
    Location:
    15; 15 D3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (72973474..73056796, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (73101625..73184947, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (72932055..73015377, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 9 Neighboring gene VISTA enhancer mm1679 Neighboring gene chromatin accessibility complex 1 Neighboring gene predicted gene, 31725 Neighboring gene PTK2 protein tyrosine kinase 2 Neighboring gene microRNA 151 Neighboring gene predicted gene, 41344

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4215

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endoribonuclease activity, cleaving miRNA-paired mRNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables endoribonuclease activity, cleaving siRNA-paired mRNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA cap binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables miRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA secondary structure unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene silencing by RNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA cleavage involved in gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA cleavage involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA cleavage involved in gene silencing by siRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA loading onto RISC involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within miRNA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of amyloid precursor protein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of miRNA mediated inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation, ncRNA-mediated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within production of miRNAs involved in gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in siRNA loading onto RISC involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC-loading complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mRNA cap binding complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of polysome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein argonaute-2
    Names
    Piwi/Argonaute family protein meIF2C2
    argonaute 2
    argonaute RISC catalytic component 2
    eukaryotic translation initiation factor 2C, 2
    NP_694818.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153178.4NP_694818.3  protein argonaute-2

      See identical proteins and their annotated locations for NP_694818.3

      Status: VALIDATED

      Source sequence(s)
      AC118640, AC161581, AK142854, AK220193, BE650477, BY732637
      Consensus CDS
      CCDS37098.1
      UniProtKB/Swiss-Prot
      Q8CJG0
      UniProtKB/TrEMBL
      Q3UQ34
      Related
      ENSMUSP00000042207.10, ENSMUST00000044113.12
      Conserved Domains (2) summary
      PLN03202
      Location:7859
      PLN03202; protein argonaute; Provisional
      cd04657
      Location:393818
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      72973474..73056796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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