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    Mkrn1 makorin, ring finger protein, 1 [ Mus musculus (house mouse) ]

    Gene ID: 54484, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mkrn1provided by MGI
    Official Full Name
    makorin, ring finger protein, 1provided by MGI
    Primary source
    MGI:MGI:1859353
    See related
    Ensembl:ENSMUSG00000029922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RFP
    Expression
    Ubiquitous expression in testis adult (RPKM 72.2), liver E14.5 (RPKM 30.0) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mkrn1 in Genome Data Viewer
    Location:
    6; 6 B1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39374738..39400480, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39397804..39423299, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (39347820..39370368, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 3 Neighboring gene RAB19, member RAS oncogene family Neighboring gene predicted gene 10244 Neighboring gene predicted gene, 25402 Neighboring gene DENN/MADD domain containing 2A Neighboring gene predicted gene, 52860 Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase makorin-1
    Names
    RING-type E3 ubiquitin transferase makorin-1
    NP_001298038.1
    NP_061280.2
    XP_011239713.1
    XP_011239714.1
    XP_011239715.1
    XP_017177172.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311109.1NP_001298038.1  E3 ubiquitin-protein ligase makorin-1 isoform 2

      See identical proteins and their annotated locations for NP_001298038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 2.
      Source sequence(s)
      AK029500, AK077060, BM933910, BP761527
      Consensus CDS
      CCDS80528.1
      UniProtKB/TrEMBL
      E9QAG7, Q8C5V4
      Related
      ENSMUSP00000110471.2, ENSMUST00000114823.8
      Conserved Domains (4) summary
      PHA03096
      Location:157306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:336415
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:2644
      zf_CCCH_4; Zinc finger domain
    2. NM_018810.2NP_061280.2  E3 ubiquitin-protein ligase makorin-1 isoform 1

      See identical proteins and their annotated locations for NP_061280.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK077060
      Consensus CDS
      CCDS20022.1
      UniProtKB/TrEMBL
      Q8C5V4
      Related
      ENSMUSP00000031985.7, ENSMUST00000031985.13
      Conserved Domains (5) summary
      PHA03096
      Location:221370
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:278338
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:400479
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18044
      Location:5980
      zf-CCCH_4; CCCH-type zinc finger
      pfam18345
      Location:90108
      zf_CCCH_4; Zinc finger domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39374738..39400480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321683.2XP_017177172.1  E3 ubiquitin-protein ligase makorin-1 isoform X1

      UniProtKB/TrEMBL
      Q8C5V4
      Conserved Domains (5) summary
      PHA03096
      Location:221370
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:278338
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:400479
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18044
      Location:5980
      zf-CCCH_4; CCCH-type zinc finger
      pfam18345
      Location:90108
      zf_CCCH_4; Zinc finger domain
    2. XM_011241412.4XP_011239714.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      See identical proteins and their annotated locations for XP_011239714.1

      UniProtKB/TrEMBL
      E9QAG7
      Conserved Domains (4) summary
      PHA03096
      Location:157306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:336415
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:2644
      zf_CCCH_4; Zinc finger domain
    3. XM_011241411.4XP_011239713.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      See identical proteins and their annotated locations for XP_011239713.1

      UniProtKB/TrEMBL
      E9QAG7
      Conserved Domains (4) summary
      PHA03096
      Location:157306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:336415
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:2644
      zf_CCCH_4; Zinc finger domain
    4. XM_011241413.4XP_011239715.1  E3 ubiquitin-protein ligase makorin-1 isoform X2

      See identical proteins and their annotated locations for XP_011239715.1

      UniProtKB/TrEMBL
      E9QAG7
      Conserved Domains (4) summary
      PHA03096
      Location:157306
      PHA03096; p28-like protein; Provisional
      cd16730
      Location:214274
      RING-HC_MKRN1_3; RING finger, HC subclass, found in makorin-1 (MKRN1), makorin-3 (MKRN3), and similar proteins
      pfam15815
      Location:336415
      MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal
      pfam18345
      Location:2644
      zf_CCCH_4; Zinc finger domain
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