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    Tesk2 testis-specific kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 230661, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tesk2provided by MGI
    Official Full Name
    testis-specific kinase 2provided by MGI
    Primary source
    MGI:MGI:2385204
    See related
    Ensembl:ENSMUSG00000033985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in testis adult (RPKM 12.8), large intestine adult (RPKM 7.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Tesk2 in Genome Data Viewer
    Location:
    4; 4 D1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116578107..116661450)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116720909..116804248)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (116393560..116476853)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AV051173 Neighboring gene peroxiredoxin 1 Neighboring gene methylmalonic aciduria cblC type, with homocystinuria Neighboring gene coiled-coil domain containing 163 Neighboring gene target of EGR1, member 1 (nuclear) Neighboring gene mutY DNA glycosylase Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29168

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity testis-specific protein kinase 2
    Names
    testicular protein kinase 2
    NP_666263.3
    XP_006503071.1
    XP_030109303.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146151.4NP_666263.3  dual specificity testis-specific protein kinase 2

      See identical proteins and their annotated locations for NP_666263.3

      Status: VALIDATED

      Source sequence(s)
      AK047755, AL683847
      Consensus CDS
      CCDS18516.1
      UniProtKB/Swiss-Prot
      Q8VCT9
      Related
      ENSMUSP00000041009.7, ENSMUST00000045542.13
      Conserved Domains (2) summary
      smart00219
      Location:62309
      TyrKc; Tyrosine kinase, catalytic domain
      cd14155
      Location:64316
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116578107..116661450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253443.2XP_030109303.1  dual specificity testis-specific protein kinase 2 isoform X1

      Conserved Domains (1) summary
      cd14155
      Location:144396
      PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase
    2. XM_006503008.5XP_006503071.1  dual specificity testis-specific protein kinase 2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1200
      PKc_like; Protein Kinases, catalytic domain
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