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    Stard10 StAR related lipid transfer domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 56018, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Stard10provided by MGI
    Official Full Name
    StAR related lipid transfer domain containing 10provided by MGI
    Primary source
    MGI:MGI:1860093
    See related
    Ensembl:ENSMUSG00000030688 AllianceGenome:MGI:1860093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCTP2; Pctpl; CGI-52; PC-TP2; TISP-81; NY-C0-28; Sdccag28; SdccagG28
    Summary
    Predicted to enable lipid binding activity. Acts upstream of or within bile acid secretion and positive regulation of peroxisome proliferator activated receptor signaling pathway. Located in several cellular components, including cytosol; intercellular canaliculus; and microvillus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and liver and biliary system. Orthologous to human STARD10 (StAR related lipid transfer domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 468.9), colon adult (RPKM 328.7) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E2; 7 54.55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100966293..100995833)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101317086..101346626)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FCH and double SH3 domains 2 Neighboring gene predicted gene, 57508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:108450776-108450959 Neighboring gene STARR-seq mESC enhancer starr_19689 Neighboring gene STARR-positive B cell enhancer ABC_E1349 Neighboring gene autophagy related 16 like 2 Neighboring gene predicted gene 20476 Neighboring gene STARR-seq mESC enhancer starr_19692 Neighboring gene STARR-positive B cell enhancer ABC_E4957 Neighboring gene predicted gene, 35219 Neighboring gene STARR-positive B cell enhancer ABC_E1740 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene phosphodiesterase 2A, cGMP-stimulated Neighboring gene microRNA 139

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of phosphatidylcholine transfer protein-like protein gene expressed in murine haploid germ cells. Yamanaka M, et al. Biol Reprod, 2000 Jun. PMID 10819773
    2. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Carrat GR, et al. Mol Metab, 2020 Oct. PMID 32416313, Free PMC Article
    3. Star-related lipid transfer protein 10 (STARD10): a novel key player in alcohol-induced breast cancer progression. Floris A, et al. J Exp Clin Cancer Res, 2019 Jan 5. PMID 30611309, Free PMC Article
    4. Transcriptional profiling of the heart reveals chamber-specific gene expression patterns. Tabibiazar R, et al. Circ Res, 2003 Dec 12. PMID 14576202
    5. Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells. Lin S, et al. J Biol Chem, 2015 Jul 24. PMID 26048993, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
      Title: The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
    2. StarD10 is required for normal insulin secretion, though its deletion enhances proinsulin processing.
      Title: Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.
    3. LPCAT1 interacts with StarD10 and that amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction.
      Title: Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells.
    4. results indicate that STARD10 is involved in regulating bile acid metabolism through the modulation of PPARalpha-mediated mechanism.
      Title: Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.
    5. Stard10 (Sdccag28) is much more highly transcribed in cardiac atria than in cardiac ventricles.
      Title: Transcriptional profiling of the heart reveals chamber-specific gene expression patterns.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bile acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of peroxisome proliferator activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intercellular canaliculus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intercellular canaliculus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    START domain-containing protein 10
    Names
    PCTP-L
    PCTP-like protein
    START domain containing 10
    serologically defined colon cancer antigen 10
    serologically defined colon cancer antigen 28 homolog
    stAR-related lipid transfer protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360460.1 → NP_001347389.1  START domain-containing protein 10 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC107638, AC129079
      Consensus CDS
      CCDS90281.1
      UniProtKB/TrEMBL
      E9PVP0, Q5RL65
      Related
      ENSMUSP00000129408.3, ENSMUST00000163799.9
      Conserved Domains (1) summary
      cd08871
      Location:92 → 314
      START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins

    2. NM_019990.5 → NP_064374.1  START domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_064374.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC129079
      Consensus CDS
      CCDS21509.1
      UniProtKB/Swiss-Prot
      Q9JMD3
      UniProtKB/TrEMBL
      Q0VG22, Q52LA1
      Related
      ENSMUSP00000032927.8, ENSMUST00000032927.14
      Conserved Domains (1) summary
      cd08871
      Location:19 → 241
      START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100966293..100995833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153267.1 → XP_036009160.1  START domain-containing protein 10 isoform X1

      UniProtKB/Swiss-Prot
      Q9JMD3
      UniProtKB/TrEMBL
      Q0VG22, Q52LA1
      Conserved Domains (1) summary
      cd08871
      Location:19 → 241
      START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins

    2. XM_030242807.1 → XP_030098667.1  START domain-containing protein 10 isoform X1

      UniProtKB/Swiss-Prot
      Q9JMD3
      UniProtKB/TrEMBL
      Q0VG22, Q52LA1
      Related
      ENSMUSP00000133002.3, ENSMUST00000164479.9
      Conserved Domains (1) summary
      cd08871
      Location:19 → 241
      START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMD3.1 GenPept UniProtKB/Swiss-Prot:Q9JMD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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