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    Slco1c1 solute carrier organic anion transporter family, member 1c1 [ Mus musculus (house mouse) ]

    Gene ID: 58807, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slco1c1provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 1c1provided by MGI
    Primary source
    MGI:MGI:1889679
    See related
    Ensembl:ENSMUSG00000030235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OAT; Oatp2; Oatpf; Slc21; OATP-F; OATP-14; Slc21a14
    Expression
    Biased expression in frontal lobe adult (RPKM 12.2), cortex adult (RPKM 11.8) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slco1c1 in Genome Data Viewer
    Location:
    6; 6 G2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (141470080..141515903)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (141524354..141570177)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (141472907..141518698)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A, cGMP inhibited Neighboring gene predicted gene 10400 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene solute carrier organic anion transporter family, member 1b2 Neighboring gene predicted gene 5724

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90655

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of thyroid hormone generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in thyroid hormone transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier organic anion transporter family member 1C1
    Names
    organic anion transporter 2
    organic anion transporter F
    organic anion-transporting polypeptide 14
    solute carrier family 21 (organic anion transporter), member 14
    thyroxine transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177772.2NP_001171243.1  solute carrier organic anion transporter family member 1C1 isoform 2

      See identical proteins and their annotated locations for NP_001171243.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. An in-frame AUG is located one codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AC153834, AC155835
      UniProtKB/Swiss-Prot
      Q9ERB5
      Conserved Domains (3) summary
      cd06174
      Location:46302
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:475528
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44640
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. NM_021471.3NP_067446.1  solute carrier organic anion transporter family member 1C1 isoform 1

      See identical proteins and their annotated locations for NP_067446.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). An in-frame AUG is located one codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.
      Source sequence(s)
      AC153834, AC155835
      Consensus CDS
      CCDS20677.1
      UniProtKB/Swiss-Prot
      Q9ERB5
      Related
      ENSMUSP00000032362.10, ENSMUST00000032362.12
      Conserved Domains (3) summary
      cd06174
      Location:46302
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:475528
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:44641
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RNA

    1. NR_149743.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate, frame-shifting splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the canonical translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC153834, AC155835
      Related
      ENSMUST00000135562.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      141470080..141515903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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