Slco1c1 solute carrier organic anion transporter family, member 1c1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slco1c1provided by MGI
Official Full Name: solute carrier organic anion transporter family, member 1c1provided by MGI
Primary source: MGI:MGI:1889679
See related: Ensembl:ENSMUSG00000030235 AllianceGenome:MGI:1889679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oatp2; Oatpf; OATP-F; OATP-14; Slc21a14
Summary: Predicted to enable bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Predicted to be involved in several processes, including organic anion transport; positive regulation of thyroid hormone generation; and thyroid hormone transport. Predicted to act upstream of or within ion transport. Located in basolateral plasma membrane. Is expressed in blood vessel; central nervous system; cochlea; and retina. Orthologous to human SLCO1C1 (solute carrier organic anion transporter family member 1C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 12.2), cortex adult (RPKM 11.8) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G2; 6 72.38 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (141470080..141515903)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (141524354..141570177)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
Title: Brain Gene Expression in Systemic Hypothyroidism and Mouse Models of MCT8 Deficiency: The Mct8-Oatp1c1-Dio2 Triad.
Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
Title: Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.
Our data provide solid evidence for a unique gate-keeper function of MCT8 and OATP1C1 in SC activation, underscoring the importance of a finely tuned TH signaling during myogenesis.
Title: Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration.
This study identified the thyroid hormone transporter OATP1C1 as the SR101-uptake transporter in hippocampus and cortex
Title: The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.
The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents.
Title: Parallel regulation of thyroid hormone transporters OATP1c1 and MCT8 during and after endotoxemia at the blood-brain barrier of male rodents.
Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
Title: Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis.
SLCO1C1 is expressed in the neuronal cell lineage during brain development. Expression of SLCO1C1 may underlie the extraordinary sensitivity of specific neuronal populations to hypothyroxinaemia.
Title: A transgenic approach to identify thyroxine transporter-expressing structures in brain development.
expression of candidate thyroid hormone transporters Lat1, Mct8, Mct10, and Oatp1c1 in mouse cochlear development
Title: Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea.
OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels.
Title: Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.
basolateral localization of mOatp14 in the choroid plexus in which it may also play a role in T4 uptake.
Title: Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H05L03.2 (e-PCR)
- UniSTS:311318

Slco1c1 (e-PCR), detects polymorphism
- UniSTS:547399

Slco1c1 (e-PCR), detects polymorphism
- UniSTS:546035

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 1C1

Names: organic anion transporter 2; organic anion transporter F; organic anion-transporting polypeptide 14; solute carrier family 21 (organic anion transporter), member 14; thyroxine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177772.2 → NP_001171243.1 solute carrier organic anion transporter family member 1C1 isoform 2

See identical proteins and their annotated locations for NP_001171243.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. An in-frame AUG is located one codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.

Source sequence(s)

AC153834, AC155835

UniProtKB/TrEMBL

A0A0N4SUZ6

Conserved Domains (3) summary

cd06174
Location:46 → 302

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:475 → 528

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:44 → 640

OATP; Organic Anion Transporter Polypeptide (OATP) family
NM_021471.3 → NP_067446.1 solute carrier organic anion transporter family member 1C1 isoform 1

See identical proteins and their annotated locations for NP_067446.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). An in-frame AUG is located one codon upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context.

Source sequence(s)

AC153834, AC155835

Consensus CDS

CCDS20677.1

UniProtKB/Swiss-Prot

Q8BX54, Q9ERB5

UniProtKB/TrEMBL

A0A0N4SUZ6

Related

ENSMUSP00000032362.10, ENSMUST00000032362.12

Conserved Domains (3) summary

cd06174
Location:46 → 302

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:475 → 528

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

pfam03137
Location:44 → 641

OATP; Organic Anion Transporter Polypeptide (OATP) family

RNA

NR_149743.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate, frame-shifting splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the canonical translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC153834, AC155835

Related

ENSMUST00000135562.8