U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Otud5 OTU domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 54644, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Otud5provided by MGI
    Official Full Name
    OTU domain containing 5provided by MGI
    Primary source
    MGI:MGI:1859615
    See related
    Ensembl:ENSMUSG00000031154 AllianceGenome:MGI:1859615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DUBA; Sfc7; DXImx46e
    Summary
    Predicted to enable Lys48-specific deubiquitinase activity; Lys63-specific deubiquitinase activity; and thiol-dependent deubiquitinase. Acts upstream of or within several processes, including alpha-beta T cell differentiation; negative regulation of interleukin-17 production; and regulation of T-helper 17 type immune response. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.1), spleen adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    X A1.1; X 3.54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7705852..7742861)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7839613..7876626)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene GRIP1 associated protein 1 Neighboring gene microRNA 1198 Neighboring gene potassium voltage-gated channel, Shal-related family, member 1 Neighboring gene STARR-seq mESC enhancer starr_46674 Neighboring gene STARR-positive B cell enhancer ABC_E11045 Neighboring gene proviral integration site 2 Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING. Guo Y, et al. Cell Mol Immunol, 2021 Aug. PMID 32879469, Free PMC Article
    2. OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity. Li F, et al. Nat Commun, 2020 Aug 21. PMID 32826889, Free PMC Article
    3. Phosphorylation-dependent activity of the deubiquitinase DUBA. Huang OW, et al. Nat Struct Mol Biol, 2012 Jan 15. PMID 22245969
    4. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Rutz S, et al. Nature, 2015 Feb 19. PMID 25470037
    5. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, et al. Nat Genet, 2001 Jan. PMID 11138001

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis.
      Title: Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis.
    2. OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING.
      Title: OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING.
    3. OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.
      Title: OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.
    4. data identify DUBA as a cell-intrinsic suppressor of IL-17 production
      Title: Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ12550

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T-helper 17 cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interleukin-21 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interleukin-9 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-17 production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neural crest cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of T-helper 17 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    OTU domain-containing protein 5
    Names
    deubiquinating enzyme A
    deubiquitinating enzyme A
    NP_001277465.1
    NP_001277466.1
    NP_001413225.1
    NP_001413227.1
    NP_613070.2
    XP_006527728.1
    XP_006527729.1
    XP_030107258.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290536.2 → NP_001277465.1  OTU domain-containing protein 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AL671978, AL671995
      Consensus CDS
      CCDS72336.1
      UniProtKB/TrEMBL
      A2AES4, A2AES5
      Related
      ENSMUSP00000111330.2, ENSMUST00000115666.8
      Conserved Domains (1) summary
      cl19932
      Location:221 → 332
      OTU; OTU-like cysteine protease

    2. NM_001290537.2 → NP_001277466.1  OTU domain-containing protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment of the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL671978, AL671995
      Consensus CDS
      CCDS72335.1
      UniProtKB/TrEMBL
      A2AES3
      Related
      ENSMUSP00000111332.4, ENSMUST00000115668.10
      Conserved Domains (1) summary
      cl19932
      Location:178 → 287
      OTU; OTU-like cysteine protease

    3. NM_001426296.1 → NP_001413225.1  OTU domain-containing protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL671978, AL671995
      UniProtKB/TrEMBL
      A2AES5

    4. NM_001426298.1 → NP_001413227.1  OTU domain-containing protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671978, AL671995
      UniProtKB/Swiss-Prot
      Q3U2S4, Q3UE33, Q91YL5, Q9CV50, Q9JIG6

    5. NM_138604.4 → NP_613070.2  OTU domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_613070.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 both encode the same isoform (2).
      Source sequence(s)
      AL671978, AL671995
      Consensus CDS
      CCDS29975.1
      UniProtKB/Swiss-Prot
      Q3U2S4, Q3UE33, Q91YL5, Q9CV50, Q9JIG6
      UniProtKB/TrEMBL
      A2AES4
      Related
      ENSMUSP00000033494.10, ENSMUST00000033494.16
      Conserved Domains (1) summary
      cl19932
      Location:221 → 332
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7705852..7742861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527666.4 → XP_006527729.1  OTU domain-containing protein 5 isoform X4

      UniProtKB/TrEMBL
      A2AES4
      Conserved Domains (1) summary
      cl19932
      Location:221 → 332
      OTU; OTU-like cysteine protease

    2. XM_006527665.5 → XP_006527728.1  OTU domain-containing protein 5 isoform X3

      UniProtKB/TrEMBL
      A2AES4
      Conserved Domains (1) summary
      cl19932
      Location:220 → 331
      OTU; OTU-like cysteine protease

    3. XM_030251398.2 → XP_030107258.1  OTU domain-containing protein 5 isoform X5

      UniProtKB/TrEMBL
      A2AES3
      Conserved Domains (1) summary
      cl19932
      Location:177 → 288
      OTU; OTU-like cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2S4.2 GenPept UniProtKB/Swiss-Prot:Q3U2S4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous