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    Otud5 OTU domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 54644, updated on 8-Jul-2021

    Summary

    Official Symbol
    Otud5provided by MGI
    Official Full Name
    OTU domain containing 5provided by MGI
    Primary source
    MGI:MGI:1859615
    See related
    Ensembl:ENSMUSG00000031154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dub; Sfc; DUBA; Sfc7; DXImx46; AA407879; AI553596; BB114028; DXImx46e
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.1), spleen adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Otud5 in Genome Data Viewer
    Location:
    X A1.1; X 3.54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7705852..7742865)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7839613..7876626)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7418957..7451986)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene GRIP1 associated protein 1 Neighboring gene microRNA 1198 Neighboring gene potassium voltage-gated channel, Shal-related family, member 1 Neighboring gene proviral integration site 2 Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12550

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Lys48-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables Lys63-specific deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Lys63-specific deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thiol-dependent deubiquitinase ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T-helper 17 cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-21 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within interleukin-9 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of interleukin-17 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of T-helper 17 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    OTU domain-containing protein 5
    Names
    deubiquinating enzyme A
    deubiquitinating enzyme A
    NP_001277465.1
    NP_001277466.1
    NP_613070.2
    XP_006527728.1
    XP_006527729.1
    XP_017174053.1
    XP_030107257.1
    XP_030107258.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290536.1NP_001277465.1  OTU domain-containing protein 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL671978, AL671995
      Consensus CDS
      CCDS72336.1
      UniProtKB/TrEMBL
      A2AES5
      Related
      ENSMUSP00000111330.2, ENSMUST00000115666.8
      Conserved Domains (1) summary
      cl19932
      Location:221332
      OTU; OTU-like cysteine protease
    2. NM_001290537.1NP_001277466.1  OTU domain-containing protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment of the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK149777, AL671978, BY132653
      Consensus CDS
      CCDS72335.1
      UniProtKB/Swiss-Prot
      Q3U2S4
      Related
      ENSMUSP00000111332.4, ENSMUST00000115668.10
      Conserved Domains (1) summary
      cl19932
      Location:178287
      OTU; OTU-like cysteine protease
    3. NM_138604.3NP_613070.2  OTU domain-containing protein 5 isoform 2

      See identical proteins and their annotated locations for NP_613070.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL671978, AL671995
      Consensus CDS
      CCDS29975.1
      UniProtKB/Swiss-Prot
      Q3U2S4
      Related
      ENSMUSP00000033494.10, ENSMUST00000033494.16
      Conserved Domains (1) summary
      cl19932
      Location:221332
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7705852..7742865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527666.4XP_006527729.1  OTU domain-containing protein 5 isoform X4

      Conserved Domains (1) summary
      cl19932
      Location:221332
      OTU; OTU-like cysteine protease
    2. XM_006527665.5XP_006527728.1  OTU domain-containing protein 5 isoform X3

      Conserved Domains (1) summary
      cl19932
      Location:220331
      OTU; OTU-like cysteine protease
    3. XM_030251398.2XP_030107258.1  OTU domain-containing protein 5 isoform X5

      Conserved Domains (1) summary
      cl19932
      Location:177288
      OTU; OTU-like cysteine protease
    4. XM_017318564.3XP_017174053.1  OTU domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A2AES5
      Conserved Domains (1) summary
      cl19932
      Location:221332
      OTU; OTU-like cysteine protease
    5. XM_030251397.2XP_030107257.1  OTU domain-containing protein 5 isoform X2

      Related
      ENSMUSP00000111331.4, ENSMUST00000115667.10
      Conserved Domains (1) summary
      cl19932
      Location:221332
      OTU; OTU-like cysteine protease
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