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    Mylip myosin regulatory light chain interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 218203, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mylipprovided by MGI
    Official Full Name
    myosin regulatory light chain interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2388271
    See related
    Ensembl:ENSMUSG00000038175
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I; M; Mir; 9430057C20Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 23.3), mammary gland adult (RPKM 20.8) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mylip in Genome Data Viewer
    Location:
    13; 13 A5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (45543197..45565498)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (45389742..45411940)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (45485111..45507309)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34466 Neighboring gene predicted gene, 40933 Neighboring gene predicted gene, 53792 Neighboring gene guanosine monophosphate reductase Neighboring gene predicted gene, 34582

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC11702

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MYLIP
    Names
    RING-type E3 ubiquitin transferase MYLIP
    idol
    inducible degrader of the LDL-receptor
    NP_722484.2
    XP_036013884.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153789.3NP_722484.2  E3 ubiquitin-protein ligase MYLIP

      See identical proteins and their annotated locations for NP_722484.2

      Status: PROVISIONAL

      Source sequence(s)
      AC154521
      Consensus CDS
      CCDS36648.1
      UniProtKB/Swiss-Prot
      Q8BM54
      Related
      ENSMUSP00000047403.10, ENSMUST00000038275.11
      Conserved Domains (5) summary
      smart00295
      Location:5190
      B41; Band 4.1 homologues
      cd13195
      Location:185295
      FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
      pfam00373
      Location:85190
      FERM_M; FERM central domain
      pfam09379
      Location:567
      FERM_N; FERM N-terminal domain
      pfam13920
      Location:383428
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      45543197..45565498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157991.1XP_036013884.1  E3 ubiquitin-protein ligase MYLIP isoform X1

      Conserved Domains (2) summary
      cd13195
      Location:4114
      FERM_C_MYLIP_IDOL; FERM domain C-lobe of E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP; also called inducible degrader of the LDL receptor, IDOL)
      cd16523
      Location:205242
      RING-HC_MYLIP; RING finger, HC subclass, found in myosin regulatory light chain interacting protein (MYLIP) and similar proteins
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