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    Arhgap4 Rho GTPase activating protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 171207, updated on 23-Jun-2021

    Summary

    Official Symbol
    Arhgap4provided by MGI
    Official Full Name
    Rho GTPase activating protein 4provided by MGI
    Primary source
    MGI:MGI:2159577
    See related
    Ensembl:ENSMUSG00000031389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    c1; Rgc; Rgc1; mKIAA0131; A130009C12Rik; A530015A20Rik
    Expression
    Biased expression in thymus adult (RPKM 79.1), spleen adult (RPKM 57.3) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arhgap4 in Genome Data Viewer
    Location:
    X; X A7.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72937958..72954945, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73894352..73911345, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71139691..71156637, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 4 Neighboring gene predicted gene, 23615 Neighboring gene L1 cell adhesion molecule Neighboring gene arginine vasopressin receptor 2 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC124367, MGC124368

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 4
    Names
    GTPase-activating protein p115

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162423.1NP_001155895.1  rho GTPase-activating protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AK028789, AK040687, AL672002
      Consensus CDS
      CCDS53101.1
      UniProtKB/TrEMBL
      B1AUY2, Q8BM00
      Related
      ENSMUSP00000110046.2, ENSMUST00000114404.8
      Conserved Domains (3) summary
      cd07656
      Location:26292
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:514690
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:748802
      SH3; Src Homology 3 domain superfamily
    2. NM_001162424.1NP_001155896.1  rho GTPase-activating protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001155896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AK028789, AK040687, AL672002
      Consensus CDS
      CCDS53100.1
      UniProtKB/TrEMBL
      B1AUX5, Q8BM00
      Related
      ENSMUSP00000110049.3, ENSMUST00000114407.9
      Conserved Domains (3) summary
      cd07656
      Location:26271
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:493680
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:738792
      SH3; Src Homology 3 domain superfamily
    3. NM_138630.2NP_619536.2  rho GTPase-activating protein 4 isoform 1

      See identical proteins and their annotated locations for NP_619536.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK028789, AK040687, AL672002
      Consensus CDS
      CCDS41014.1
      UniProtKB/TrEMBL
      Q80Z68, Q8BM00
      Related
      ENSMUSP00000067477.7, ENSMUST00000064376.13
      Conserved Domains (3) summary
      cd07656
      Location:26292
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:514701
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:759813
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72937958..72954945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247535.4XP_011245837.1  rho GTPase-activating protein 4 isoform X6

      Related
      ENSMUSP00000110048.3, ENSMUST00000114406.9
      Conserved Domains (4) summary
      COG1196
      Location:141377
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl02570
      Location:401588
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:30242
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl17036
      Location:652706
      SH3; Src Homology 3 domain superfamily
    2. XM_011247531.4XP_011245833.1  rho GTPase-activating protein 4 isoform X2

      Conserved Domains (3) summary
      cd07656
      Location:26292
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:514701
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:765819
      SH3; Src Homology 3 domain superfamily
    3. XM_011247533.4XP_011245835.1  rho GTPase-activating protein 4 isoform X4

      Conserved Domains (3) summary
      cd07656
      Location:30275
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:497684
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:748802
      SH3; Src Homology 3 domain superfamily
    4. XM_011247530.3XP_011245832.1  rho GTPase-activating protein 4 isoform X1

      Conserved Domains (3) summary
      cd07656
      Location:30296
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:518705
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:769823
      SH3; Src Homology 3 domain superfamily
    5. XM_011247532.4XP_011245834.1  rho GTPase-activating protein 4 isoform X3

      Conserved Domains (3) summary
      cd07656
      Location:30296
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:518705
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:763817
      SH3; Src Homology 3 domain superfamily
    6. XM_011247534.4XP_011245836.1  rho GTPase-activating protein 4 isoform X5

      Conserved Domains (3) summary
      cd07656
      Location:3269
      F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins
      cl02570
      Location:491678
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:742796
      SH3; Src Homology 3 domain superfamily
    7. XM_011247536.4XP_011245838.1  rho GTPase-activating protein 4 isoform X7

      Conserved Domains (2) summary
      cl02570
      Location:165352
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:416470
      SH3; Src Homology 3 domain superfamily
    8. XM_011247537.3XP_011245839.1  rho GTPase-activating protein 4 isoform X8

      Conserved Domains (2) summary
      cl02570
      Location:152339
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl17036
      Location:403457
      SH3; Src Homology 3 domain superfamily
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