Arhgap4 Rho GTPase activating protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap4provided by MGI
Official Full Name: Rho GTPase activating protein 4provided by MGI
Primary source: MGI:MGI:2159577
See related: Ensembl:ENSMUSG00000031389 AllianceGenome:MGI:2159577
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: c1; Rgc1; mKIAA0131; A130009C12Rik; A530015A20Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of cell migration. Predicted to be active in cytoplasm. Orthologous to human ARHGAP4 (Rho GTPase activating protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 79.1), spleen adult (RPKM 57.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.45 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72937958..72954945, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73894352..73911345, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRL-1 binding to p115 RhoGAP provides a coordinated mechanism underlying ERK1/2 and RhoA activation
Title: PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
The p115 Rho GAP binds to MEKK1 in vitro and in intact cells. Expression of p115 Rho GAP reduces MEKK1-induced signaling to AP-1.
Title: p115 Rho GTPase activating protein interacts with MEKK1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 4

Names: GTPase-activating protein p115

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162423.1 → NP_001155895.1 rho GTPase-activating protein 4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AK028789, AK040687, AL672002

Consensus CDS

CCDS53101.1

UniProtKB/TrEMBL

B1AUY2, Q32MS4

Related

ENSMUSP00000110046.2, ENSMUST00000114404.8

Conserved Domains (3) summary

cd07656
Location:26 → 292

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:514 → 690

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

cl17036
Location:748 → 802

SH3; Src Homology 3 domain superfamily
NM_001162424.1 → NP_001155896.1 rho GTPase-activating protein 4 isoform 3

See identical proteins and their annotated locations for NP_001155896.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.

Source sequence(s)

AK028789, AK040687, AL672002

Consensus CDS

CCDS53100.1

UniProtKB/TrEMBL

B1AUX5, Q8VHL8

Related

ENSMUSP00000110049.3, ENSMUST00000114407.9

Conserved Domains (3) summary

cd07656
Location:26 → 271

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:493 → 680

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

cl17036
Location:738 → 792

SH3; Src Homology 3 domain superfamily
NM_138630.2 → NP_619536.2 rho GTPase-activating protein 4 isoform 1

See identical proteins and their annotated locations for NP_619536.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK028789, AK040687, AL672002

Consensus CDS

CCDS41014.1

UniProtKB/TrEMBL

Q80Z68, Q8VHL8

Related

ENSMUSP00000067477.7, ENSMUST00000064376.13

Conserved Domains (3) summary

cd07656
Location:26 → 292

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:514 → 701

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

cl17036
Location:759 → 813

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

72937958..72954945 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247535.4 → XP_011245837.1 rho GTPase-activating protein 4 isoform X6

UniProtKB/TrEMBL

Q3TE27

Related

ENSMUSP00000110048.3, ENSMUST00000114406.9

Conserved Domains (4) summary

COG1196
Location:141 → 377

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl02570
Location:401 → 588

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl12013
Location:30 → 242

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

cl17036
Location:652 → 706

SH3; Src Homology 3 domain superfamily
XM_011247531.4 → XP_011245833.1 rho GTPase-activating protein 4 isoform X2

UniProtKB/TrEMBL

Q8VHL8

Conserved Domains (3) summary

cd07656
Location:26 → 292

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:514 → 701

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl17036
Location:765 → 819

SH3; Src Homology 3 domain superfamily
XM_011247533.4 → XP_011245835.1 rho GTPase-activating protein 4 isoform X4

UniProtKB/TrEMBL

Q8VHL8

Conserved Domains (3) summary

cd07656
Location:30 → 275

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:497 → 684

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl17036
Location:748 → 802

SH3; Src Homology 3 domain superfamily
XM_011247530.3 → XP_011245832.1 rho GTPase-activating protein 4 isoform X1

UniProtKB/TrEMBL

Q8VHL8

Conserved Domains (3) summary

cd07656
Location:30 → 296

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:518 → 705

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl17036
Location:769 → 823

SH3; Src Homology 3 domain superfamily
XM_011247532.4 → XP_011245834.1 rho GTPase-activating protein 4 isoform X3

UniProtKB/TrEMBL

Q8VHL8

Conserved Domains (3) summary

cd07656
Location:30 → 296

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:518 → 705

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl17036
Location:763 → 817

SH3; Src Homology 3 domain superfamily
XM_011247534.4 → XP_011245836.1 rho GTPase-activating protein 4 isoform X5

UniProtKB/TrEMBL

Q8VHL8

Conserved Domains (3) summary

cd07656
Location:3 → 269

F-BAR_srGAP; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Proteins

cl02570
Location:491 → 678

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl17036
Location:742 → 796

SH3; Src Homology 3 domain superfamily
XM_011247536.4 → XP_011245838.1 rho GTPase-activating protein 4 isoform X7

UniProtKB/TrEMBL

Q8BM00

Conserved Domains (2) summary

cl02570
Location:165 → 352

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl17036
Location:416 → 470

SH3; Src Homology 3 domain superfamily
XM_011247537.3 → XP_011245839.1 rho GTPase-activating protein 4 isoform X8

UniProtKB/TrEMBL

Q8BM00

Conserved Domains (2) summary

cl02570
Location:152 → 339

RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

cl17036
Location:403 → 457

SH3; Src Homology 3 domain superfamily