Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Nek5 NIMA (never in mitosis gene a)-related expressed kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 330721, updated on 5-Sep-2021

    Summary

    Official Symbol
    Nek5provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 5provided by MGI
    Primary source
    MGI:MGI:2142824
    See related
    Ensembl:ENSMUSG00000037738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BB049667; 6530411J22
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nek5 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22563631..22615443, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22073615..22125418, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23184088..23235525, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATPase, Cu++ transporting, beta polypeptide Neighboring gene asparagine-linked glycosylation 11 (alpha-1,2-mannosyltransferase) Neighboring gene small nucleolar RNA U13 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 3 Neighboring gene cytoskeleton associated protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek5
    Names
    never in mitosis A-related kinase 5
    nimA-related protein kinase 5
    NP_001334247.1
    NP_808566.2
    XP_006509217.1
    XP_006509218.1
    XP_006509222.1
    XP_011240445.1
    XP_011240446.1
    XP_011240447.1
    XP_011240448.1
    XP_011240449.1
    XP_011240451.1
    XP_017168352.1
    XP_030099482.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347318.2NP_001334247.1  serine/threonine-protein kinase Nek5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
      Source sequence(s)
      AK032672, AK054168, BC053516
      Consensus CDS
      CCDS85511.1
      UniProtKB/Swiss-Prot
      Q7TSC3
      Related
      ENSMUSP00000148211.2, ENSMUST00000209656.2
    2. NM_177898.5NP_808566.2  serine/threonine-protein kinase Nek5 isoform 1

      See identical proteins and their annotated locations for NP_808566.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AK032672, AK054168
      Consensus CDS
      CCDS52518.1
      UniProtKB/Swiss-Prot
      Q7TSC3
      Related
      ENSMUSP00000126705.2, ENSMUST00000169834.2
      Conserved Domains (2) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
      smart00220
      Location:4255
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22563631..22615443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242145.3XP_011240447.1  serine/threonine-protein kinase Nek5 isoform X6

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    2. XM_006509155.5XP_006509218.1  serine/threonine-protein kinase Nek5 isoform X3

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    3. XM_030243622.2XP_030099482.1  serine/threonine-protein kinase Nek5 isoform X4

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    4. XM_011242144.3XP_011240446.1  serine/threonine-protein kinase Nek5 isoform X5

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    5. XM_011242146.4XP_011240448.1  serine/threonine-protein kinase Nek5 isoform X9

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    6. XM_011242149.4XP_011240451.1  serine/threonine-protein kinase Nek5 isoform X11

    7. XM_006509154.4XP_006509217.1  serine/threonine-protein kinase Nek5 isoform X1

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    8. XM_011242143.3XP_011240445.1  serine/threonine-protein kinase Nek5 isoform X2

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    9. XM_017312863.3XP_017168352.1  serine/threonine-protein kinase Nek5 isoform X7

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    10. XM_006509159.5XP_006509222.1  serine/threonine-protein kinase Nek5 isoform X8

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    11. XM_011242147.3XP_011240449.1  serine/threonine-protein kinase Nek5 isoform X10

      Conserved Domains (1) summary
      cd08225
      Location:3255
      STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

    RNA

    1. XR_003947310.2 RNA Sequence

    2. XR_004934846.1 RNA Sequence

    Support Center