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    Jam2 junction adhesion molecule 2 [ Mus musculus (house mouse) ]

    Gene ID: 67374, updated on 23-Jun-2021

    Summary

    Official Symbol
    Jam2provided by MGI
    Official Full Name
    junction adhesion molecule 2provided by MGI
    Primary source
    MGI:MGI:1933820
    See related
    Ensembl:ENSMUSG00000053062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    JAM-; Jcam; VE-J; JAM-2; JAM-B; Jcam2; VE-JAM; 1110002N23Rik; 2410030G21Rik; 2410167M24Rik
    Expression
    Broad expression in heart adult (RPKM 20.4), frontal lobe adult (RPKM 12.0) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Jam2 in Genome Data Viewer
    Location:
    16; 16 C3.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84571011..84623268)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84774123..84826380)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (84774368..84823129)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26153 Neighboring gene predicted gene, 32202 Neighboring gene predicted gene, 46557 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F Neighboring gene GA repeat binding protein, alpha Neighboring gene predicted gene 10791 Neighboring gene amyloid beta (A4) precursor protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    NOT located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in somatodendritic compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    junctional adhesion molecule B
    Names
    junction adhesion molecule B
    junction cell adhesion molecule 2
    junctional adhesion molecule 2
    vascular endothelial junction-associated molecule

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023844.5NP_076333.3  junctional adhesion molecule B precursor

      See identical proteins and their annotated locations for NP_076333.3

      Status: VALIDATED

      Source sequence(s)
      AC164162, BC028778
      Consensus CDS
      CCDS37381.1
      UniProtKB/Swiss-Prot
      Q9JI59
      Related
      ENSMUSP00000109833.2, ENSMUST00000114195.8
      Conserved Domains (3) summary
      cd00096
      Location:47113
      Ig; Immunoglobulin domain
      smart00408
      Location:149221
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:143221
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      84571011..84623268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523075.5XP_006523138.1  junctional adhesion molecule B isoform X1

      Related
      ENSMUSP00000156235.2, ENSMUST00000231910.2
      Conserved Domains (2) summary
      smart00408
      Location:190262
      IGc2; Immunoglobulin C-2 Type
      cl11960
      Location:76151
      Ig; Immunoglobulin domain
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