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    Fbp1 fructose bisphosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14121, updated on 6-May-2021

    Summary

    Official Symbol
    Fbp1provided by MGI
    Official Full Name
    fructose bisphosphatase 1provided by MGI
    Primary source
    MGI:MGI:95492
    See related
    Ensembl:ENSMUSG00000069805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbp; Fbp-; Fbp2; Fbp3; Fbp-2
    Expression
    Biased expression in liver adult (RPKM 540.1), kidney adult (RPKM 489.1) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Fbp1 in Genome Data Viewer
    Location:
    13; 13 B3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (63012567..63036112, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (62864753..62888298, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (62966113..62989596, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene malic enzyme 1, NADP(+)-dependent, cytosolic pseudogene Neighboring gene fructose bisphosphatase 2 Neighboring gene predicted gene, 38679 Neighboring gene predicted gene, 40981 Neighboring gene tubulin, beta 2a, pseudogene 1 Neighboring gene aminopeptidase O

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fructose 1,6-bisphosphate 1-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sucrose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fructose-1,6-bisphosphatase 1
    Names
    D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
    D-fructose-1,6-bisphosphate 1-phosphohydrolase 3
    FBPase liver
    fructose-1,6-bisphosphatase isozyme 3
    liver FBPase
    NP_062268.1
    XP_011242790.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019395.3NP_062268.1  fructose-1,6-bisphosphatase 1

      See identical proteins and their annotated locations for NP_062268.1

      Status: VALIDATED

      Source sequence(s)
      AC156572, AC171004, AK149527
      Consensus CDS
      CCDS26590.1
      UniProtKB/Swiss-Prot
      Q9QXD6
      Related
      ENSMUSP00000090564.5, ENSMUST00000092888.11
      Conserved Domains (1) summary
      cd00354
      Location:18332
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      63012567..63036112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244488.2XP_011242790.1  fructose-1,6-bisphosphatase 1 isoform X1

      Conserved Domains (1) summary
      cd00354
      Location:1248
      FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
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